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肌酸激酶同工酶（CKMB）活性和蛋白浓度的测定及其在急性心肌梗死（AMI）诊断中的应用。

Determination of CKMB activity and protein concentration and their application in the diagnosis of AMI.

作者信息

Song Y, Zhong J, Zhao L, Shaoji T

机构信息

First Hospital of Wuhan City, Wuhan 430022.

出版信息

J Tongji Med Univ. 2000;20(4):301-2. doi: 10.1007/BF02888185.

DOI:10.1007/BF02888185
PMID:12840917
Abstract

The activity and protein concentration of CKMB in 19 patients with AMI, 17 non-AMI patients and 26 normal persons. It was found that both peak times in patients with AMI and non-AMI patients were similar but the peak values were different. At peak values the F value of CKMB (5.3) was much lower than that of CKMB protein concentration (50.1). We are led to conclude that the measurement of CKMB protein level can identify AMI much earlier than that of CKMB activity.

摘要

19例急性心肌梗死（AMI）患者、17例非AMI患者及26例正常人的肌酸激酶同工酶（CKMB）活性和蛋白浓度。结果发现，AMI患者和非AMI患者的峰值时间相似，但峰值不同。在峰值时，CKMB的F值（5.3）远低于CKMB蛋白浓度的F值（50.1）。由此我们得出结论，测定CKMB蛋白水平比测定CKMB活性能更早地识别AMI。

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本文引用的文献

1
Comparable detection of acute myocardial infarction by creatine kinase MB isoenzyme and cardiac troponin I.肌酸激酶同工酶MB与心肌肌钙蛋白I对急性心肌梗死的检测能力相当。
Clin Chem. 1994 Jul;40(7 Pt 1):1291-5.
2
Biochemical markers of myocardial damage.心肌损伤的生化标志物。
Clin Biochem. 1995 Feb;28(1):1-29. doi: 10.1016/0009-9120(94)00065-4.
3
Use of a rapid assay of subforms of creatine kinase MB to diagnose or rule out acute myocardial infarction.使用肌酸激酶MB亚型快速检测法诊断或排除急性心肌梗死。
N Engl J Med. 1994 Sep 1;331(9):561-6. doi: 10.1056/NEJM199409013310901.
4
Changes in the ratio of lactate dehydrogenase isoenzymes 1 and 2 during the first day after acute myocardial infarction.急性心肌梗死后第一天乳酸脱氢酶同工酶1和2比例的变化。
Clin Chem. 1985 Oct;31(10):1621-4.
5
Activity concentration and mass concentration (monoclonal antibody immunoenzymometric method) compared for creatine kinase MB isoenzyme in serum.血清中肌酸激酶MB同工酶的活性浓度与质量浓度比较（单克隆抗体免疫酶分析法）
Clin Chem. 1986 Oct;32(10):1956-9.