Monteiro H P, Abdalla D S, Arcuri A S, Bechara E J
Clin Chem. 1985 Oct;31(10):1673-6.
We evaluated superoxide dismutase (EC 1.15.1.1) and glutathione peroxidase (EC 1.11.1.9) activities in the erythrocytes of lead-exposed and nonexposed workers from distinct industries localized in the State of São Paulo, Brazil. Concentrations of either lead or protoporphyrin IX, or both, in blood were used to indicate the extent of exposure. In all cases, values for superoxide dismutase were significantly higher in the exposed workers. The dose-response relationship between this enzyme and lead concentrations was roughly linear for the workers with greater than 40 micrograms of lead per 100 g of blood. Except for the sample from one of the industries, the corresponding glutathione peroxidase activities were also significantly higher in lead-exposed workers. These data, together with those previously found for patients with intermittent acute porphyria, suggest that in both groups the accumulation of heme precursors is connected to the exacerbated production of activated oxygen species.
我们评估了巴西圣保罗州不同行业中接触铅和未接触铅工人红细胞中的超氧化物歧化酶（EC 1.15.1.1）和谷胱甘肽过氧化物酶（EC 1.11.1.9）活性。血液中铅或原卟啉IX或两者的浓度用于表明接触程度。在所有情况下，接触铅的工人中超氧化物歧化酶的值显著更高。对于每100克血液中铅含量大于40微克的工人，该酶与铅浓度之间的剂量反应关系大致呈线性。除了其中一个行业的样本外，接触铅的工人中相应的谷胱甘肽过氧化物酶活性也显著更高。这些数据，连同先前在间歇性急性卟啉症患者中发现的数据，表明在这两组中，血红素前体的积累与活性氧物种的过度产生有关。
