Wang Dongfang, Xu Bingna, Ross Brendan, Qiu Yang, Ma Zijuan, Fan Yunge, Fan Fang
School of Psychology, Centre for Studies of Psychological Applications, Guangdong Key Laboratory of Mental Health and Cognitive Science, Ministry of Education Key Laboratory of Brain Cognition and Educational Science, Guangdong Emergency Response Technology Research Center for Psychological Assistance in Emergencies, South China Normal University, Guangzhou, China.
School of Marxism, Zhejiang University, Hangzhou, China.
Eur Child Adolesc Psychiatry. 2025 May 27. doi: 10.1007/s00787-025-02753-2.
Previous work supported the opinion that sleep disturbance may cause adolescent PLEs. This study intended to evaluate the mediating effect of depressive symptoms on the relationship between change in sleep disturbance and psychotic-like experiences (PLEs) among adolescents. A total of 7529 adolescents completed three web-based surveys. Surveys were administered from April 21 to May 12, 2021 (Time 1, T1), again 6 months later from December 17 to 26, 2021 (Time 2, T2), and one year later from May 17 to June 5, 2022 (Time 3, T3). A series of self-assessment scales were used to measure sleep disturbance, depressive symptoms, PLEs, and other relevant variables. Mediation analysis was utilized to examine the association between sleep disturbance trajectories, depressive symptoms, and PLEs. Five trajectories of sleep disturbance were identified: no/low (72.2%), remission (8.8%), relapsing/remitting (7.4%), new-onset (8.9%), and persistent (2.7%) trajectories. Depressive symptoms partially mediated the effects of sleep disturbance trajectories (relative to the no/low trajectory) on PLEs (95% CIs: 0.20-0.30, 0.42-0.53, and 0.41-0.58 for relapsing/remitting, new-onset, and persistent trajectories, respectively). This study reveals that the association between sleep disturbance trajectories and PLEs was partially mediated by depressive symptoms. To prevent the onset of PLEs, early screening and interventions targeting sleep disturbance and depressive symptoms are quite essential.
先前的研究支持睡眠障碍可能导致青少年出现类精神病性体验（PLEs）这一观点。本研究旨在评估抑郁症状在青少年睡眠障碍变化与类精神病性体验（PLEs）之间关系中的中介作用。共有7529名青少年完成了三项基于网络的调查。调查于2021年4月21日至5月12日（时间1，T1）进行，6个月后的2021年12月17日至26日（时间2，T2）再次进行，一年后的2022年5月17日至6月5日（时间3，T3）进行第三次调查。使用了一系列自我评估量表来测量睡眠障碍、抑郁症状、类精神病性体验（PLEs）及其他相关变量。采用中介分析来检验睡眠障碍轨迹、抑郁症状和类精神病性体验（PLEs）之间的关联。确定了五种睡眠障碍轨迹：无/低（72.2%）、缓解（8.8%）、复发/缓解（7.4%）、新发（8.9%）和持续（2.7%）轨迹。抑郁症状部分介导了睡眠障碍轨迹（相对于无/低轨迹）对类精神病性体验（PLEs）的影响（复发/缓解、新发和持续轨迹的95%置信区间分别为0.20 - 0.30、0.42 - 0.53和0.41 - 0.58）。本研究表明，睡眠障碍轨迹与类精神病性体验（PLEs）之间的关联部分由抑郁症状介导。为预防类精神病性体验（PLEs）的发生，针对睡眠障碍和抑郁症状的早期筛查及干预至关重要。
