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基于技术的步态训练能否使患有慢性神经疾病的患者的行走功能发生相关变化?一项纵向队列研究。

Can technology-based gait training result in relevant changes of ambulatory function in people with chronic, neurological diagnoses? A longitudinal, cohort study.

作者信息

Graf Eveline S, De Bon Dino, Stahl Johanna, Degenfellner Jürgen, Knechtle Deborah, Zutter Daniel, Liberatore Florian, Wirz Markus

机构信息

School of Health Sciences, ZHAW Zurich University of Applied Sciences, Winterthur, Switzerland.

VAMED Rehazentrum Zürich Seefeld, Zurich, Switzerland.

出版信息

PLoS One. 2025 May 27;20(5):e0324062. doi: 10.1371/journal.pone.0324062. eCollection 2025.

Abstract

OBJECTIVES

To determine whether a six-months technology-based gait training results in relevant changes of ambulatory function in a chronic stage after a neurological event. Further, changes in quality of life will be assessed as well as the willingness to pay for technology-based gait training.

DESIGN

Single-center, longitudinal cohort study.

SETTING

One outpatient center specialized in neurological rehabilitation.

PARTICIPANTS

Adults with a chronic neurological diagnosis resulting in residual gait impairments.

INTERVENTION

Six month of technology-based gait training (with Lokomat, Andago, or C-Mill) with a minimal number of trainings of 10 per month.

PRIMARY & SECONDARY OUTCOME MEASURES: Walking performance assessed with the 10-meter walk test, 6-minute walk test and functional ambulation category; quality of life assessed with the EQ-5D-3L and WHODAS 2.0; predicted market share and willingness to pay assessed with a choice-based conjoint analysis survey and direct question.

RESULTS

27 participants completed three months while 20 completed six months of training. Comparing variables at baseline (BL) and after three (M3) and six (M6) months of training, both the walking speed in the 10-meter walk test (BL: 0.46m/s, M3: 0.54 m/s M6: 0.57 m/s) and the distance covered in the 6-minute walk test (BL: 149m, M3: 155m, M6: 159m) showed improvements that were below the clinically relevant change. The quality of life did not indicate a change. The direct willingness to pay was at CHF 80 which resulted in an estimated market share of 55% based on the conjoint analysis.

CONCLUSION

The observed, small changes in ambulatory function in patients with chronic, neurological impairments and the willingness to pay indicates the need to provide technology-based gait training in an outpatient setting.

摘要

目的

确定为期六个月的基于技术的步态训练是否会导致神经事件慢性期患者的步行功能发生相关变化。此外,将评估生活质量的变化以及为基于技术的步态训练付费的意愿。

设计

单中心纵向队列研究。

地点

一家专门从事神经康复的门诊中心。

参与者

患有慢性神经疾病诊断且导致残余步态障碍的成年人。

干预措施

为期六个月的基于技术的步态训练(使用Lokomat、Andago或C-Mill),每月最少训练10次。

主要和次要结局指标

通过10米步行测试、6分钟步行测试和功能性步行分类评估步行性能;使用EQ-5D-3L和WHODAS 2.0评估生活质量;通过基于选择的联合分析调查和直接提问评估预测的市场份额和付费意愿。

结果

27名参与者完成了三个月的训练,20名完成了六个月的训练。比较基线(BL)、三个月(M3)和六个月(M6)训练后的变量,10米步行测试中的步行速度(BL:0.46米/秒,M3:0.54米/秒,M6:0.57米/秒)和6分钟步行测试中的行走距离(BL:149米,M3:155米,M6:159米)均有改善,但低于临床相关变化。生活质量未显示出变化。直接付费意愿为80瑞士法郎,根据联合分析得出的估计市场份额为55%。

结论

慢性神经损伤患者步行功能的微小变化以及付费意愿表明,需要在门诊环境中提供基于技术的步态训练。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10a2/12111633/72804f2d5fa2/pone.0324062.g001.jpg

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