Intenzo C, Park C H
Clin Nucl Med. 1985 Aug;10(8):560-1. doi: 10.1097/00003072-198508000-00007.
Dual tracer parathyroid imaging (DTPI) using Tc-99m and TI-201 has a reported sensitivity of 92% for the detection of parathyroid adenomas. A patient with biopsy-proven parathyroid adenoma as well as papillary thyroid carcinoma is presented. To date, this is the first such case ever to be reported and implies that DTPI, although a sensitive diagnostic modality for parathyroid adenoma detection, is not specific. The diagnosis of primary hyperparathyroidism has recently been established more frequently than in the past due to detection of elevated serum calcium levels on routine blood samples, relatively sensitive parathormone (PTH) assays, and noninvasive imaging modalities such as nuclear medicine, CT scanning, and ultrasonography. At our institution, we have successfully detected the location of parathyroid adenomas in many cases, using the dual tracer method with TI-201 and Tc-99m, confirmed at surgery. We present a case of primary hyperparathyroidism in which two distinct lesions were detected by nuclear imaging: one lesion was proven at surgery to be a parathyroid adenoma, while the other represented thyroid carcinoma.
使用锝-99m（Tc-99m）和铊-201（TI-201）的双示踪剂甲状旁腺显像（DTPI）对甲状旁腺腺瘤检测的报告灵敏度为92%。本文介绍了一名经活检证实患有甲状旁腺腺瘤以及乳头状甲状腺癌的患者。迄今为止，这是首例此类病例报告，这意味着DTPI虽然是检测甲状旁腺腺瘤的一种敏感诊断方法，但并非特异性方法。由于在常规血液样本中检测到血清钙水平升高、相对敏感的甲状旁腺激素（PTH）检测以及核医学、CT扫描和超声检查等非侵入性成像方式，原发性甲状旁腺功能亢进的诊断近来比过去更为常见。在我们机构，我们使用TI-201和Tc-99m双示踪剂方法在许多病例中成功检测到甲状旁腺腺瘤的位置，并在手术中得到证实。我们报告一例原发性甲状旁腺功能亢进病例，通过核成像检测到两个不同的病变：其中一个病变在手术中被证实为甲状旁腺腺瘤，而另一个为甲状腺癌。
