Liese Jan, Becker Anne-Sophie
Klinik und Poliklinik für Mund‑, Kiefer- und Plastische Gesichtschirurgie, Universitätsmedizin Rostock, Rostock, Deutschland.
Institut für Pathologie, Universitätsmedizin Rostock, Strempelstr. 14, 18057, Rostock, Deutschland.
Pathologie (Heidelb). 2025 May 27. doi: 10.1007/s00292-025-01435-9.
Among non-cutaneous head and neck tumours, oral squamous cell carcinoma is one of the most common entities and is clinically characterized by functionally limiting therapies and a high recurrence rate. The majority of oral squamous cell carcinomas arise from potentially malignant diseases of the oral mucosa, which are often biopsied for preventive and diagnostic purposes. This article provides the histological criteria for grading oral epithelial dysplasia, with a scheme to help classify p53 staining and estimate prognosis. As oral cancer is still a morphologically defined entity, the histological subtypes and prognostic parameters that can be determined by light microscopy are presented. Future treatment approaches are outlined, which cannot be compared to other tumour entities due to the lack of therapeutically useful molecular alterations in oral squamous cell carcinoma.
在非皮肤性头颈部肿瘤中，口腔鳞状细胞癌是最常见的类型之一，其临床特征为功能受限的治疗方法和高复发率。大多数口腔鳞状细胞癌起源于口腔黏膜的潜在恶性疾病，这些疾病常因预防和诊断目的而进行活检。本文提供了口腔上皮发育异常分级的组织学标准，以及一个有助于对p53染色进行分类和评估预后的方案。由于口腔癌仍是一个形态学定义的实体，本文介绍了可通过光学显微镜确定的组织学亚型和预后参数。文中概述了未来的治疗方法，由于口腔鳞状细胞癌缺乏具有治疗意义的分子改变，这些方法无法与其他肿瘤类型相比较。
