He Jianfeng, Yang Linwei, Niu Chen
Department of Radiology, Guihang 300 Hospital Affiliated to Zunyi Medical University, Guiyang, China.
Department of Neurology, Guihang 300 Hospital Affiliated to Zunyi Medical University, 420 Huanghe Road, Guiyang, 550006, China.
Diagn Pathol. 2025 May 27;20(1):66. doi: 10.1186/s13000-025-01664-9.
Human pegivirus (HPgV) has been postulated as a potential etiological factor in encephalomyelitis and exhibits lymphotropic characteristics. However, the co-occurrence of encephalitis and lymphadenopathy with HPgV detected has never been reported. Herein, we report a case of a 48-year-old woman admitted with fever followed by sudden loss of consciousness. Radiological imaging demonstrated encephalitis and lymphadenopathy. Initial analysis of blood and cerebrospinal fluid (CSF) failed to reveal specific etiology. The only pathogen found in CSF was later determined to be HPgV using metagenomic next-generation sequencing (mNGS). After receiving treatment with acyclovir, meropenem, and ceftriaxone sodium, the patient fully recovered. This case contributes additional evidence in support of the hypothesis regarding the pathogenic potential of HPgV and highlights the diagnostic utility of mNGS in detecting rare pathogens.
人佩吉病毒（HPgV）被认为是脑脊髓炎的一个潜在病因，并且具有嗜淋巴细胞特性。然而，从未有过关于检测到HPgV同时并发脑炎和淋巴结病的报道。在此，我们报告一例48岁女性病例，该患者因发热入院，随后突然意识丧失。影像学检查显示有脑炎和淋巴结病。血液和脑脊液（CSF）的初步分析未能揭示具体病因。后来通过宏基因组下一代测序（mNGS）确定CSF中唯一发现的病原体是HPgV。在用阿昔洛韦、美罗培南和头孢曲松钠治疗后，患者完全康复。该病例为支持关于HPgV致病潜力的假说提供了更多证据，并突出了mNGS在检测罕见病原体方面的诊断效用。
