Nepean Hospital, PO Box 63, Penrith, NSW 2751, Australia.
Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia; Centre for Virus Research, Westmead Institute for Medical Research, Westmead, NSW 2145, Australia.
Diagn Microbiol Infect Dis. 2020 Feb;96(2):114898. doi: 10.1016/j.diagmicrobio.2019.114898. Epub 2019 Oct 5.
We describe a case of meningoencephalitis in which meta-transcriptomic (RNA) sequencing detected human pegivirus (HPgV) in brain tissue, cerebrospinal fluid, and serum in the absence of other pathogens. This is the first detection of HPgV in antemortem brain tissue, although it is uncertain whether HPgV is responsible for the observed encephalitis.
我们描述了一例脑膜脑炎,在该病例中,对元转录组(RNA)的测序在脑组织、脑脊液和血清中检测到了人类戊型肝炎病毒(HPgV),而没有检测到其他病原体。这是首次在死后脑组织中检测到 HPgV,但尚不确定 HPgV 是否是导致观察到的脑炎的原因。