Oh Man Hwan, Islam Md Minarul, Kim Nayeong, Choi Chul Hee, Shin Minsang, Shin Woo Shik, Lee Je Chul
Department of Microbiology, Dankook University, Cheonan, 31116, Republic of Korea.
Smart Animal Bio Institute, Dankook University, Cheonan, 31116, Republic of Korea.
J Biomed Sci. 2025 May 27;32(1):53. doi: 10.1186/s12929-025-01147-5.
Acinetobacter baumannii is notorious for its antimicrobial resistance and its potential to cause epidemics in hospital settings, which pose a global health threat. Although this microorganism is traditionally considered a low-virulence pathogen, extensive research has been conducted on its virulence and pathogenesis in recent years. Advances in understanding the virulence mechanisms of A. baumannii have prompted a shift in the development of anti-infective agents. The outer membrane protein A (AbOmpA) of A. baumannii is a key virulence factor both in vitro and in vivo. AbOmpA exists in three forms: outer membrane-integrated AbOmpA, outer membrane vesicle (OMV)-associated AbOmpA, and free proteins. Given that outer membrane-integrated AbOmpA has been implicated in the virulence and antimicrobial resistance of A. baumannii, many studies have focused on outer membrane-integrated AbOmpA as a therapeutic target for combating drug-resistant A. baumannii, and have led to the discovery of small molecules, polypeptides, and antimicrobial peptides targeting AbOmpA. However, the pathophysiological role of OMV-associated AbOmpA and its impact on AbOmpA-targeting agents remain unclear. This review summarizes the current knowledge of AbOmpA and critically discusses OMV-associated AbOmpA in relation to virulence and its potential impact on AbOmpA-targeted therapies to provide a better understanding of AbOmpA for the development of novel therapeutics against A. baumannii.
鲍曼不动杆菌因其抗菌耐药性以及在医院环境中引发流行的可能性而声名狼藉，这对全球健康构成了威胁。尽管这种微生物传统上被认为是低毒力病原体，但近年来对其毒力和发病机制进行了广泛研究。对鲍曼不动杆菌毒力机制理解的进展促使了抗感染药物研发方向的转变。鲍曼不动杆菌的外膜蛋白A（AbOmpA）在体外和体内都是关键的毒力因子。AbOmpA以三种形式存在：外膜整合型AbOmpA、外膜囊泡（OMV）相关型AbOmpA和游离蛋白。鉴于外膜整合型AbOmpA与鲍曼不动杆菌的毒力和抗菌耐药性有关，许多研究将外膜整合型AbOmpA作为对抗耐药鲍曼不动杆菌的治疗靶点，并发现了靶向AbOmpA的小分子、多肽和抗菌肽。然而，OMV相关型AbOmpA的病理生理作用及其对靶向AbOmpA药物的影响仍不清楚。本综述总结了关于AbOmpA的现有知识，并批判性地讨论了与毒力相关的OMV相关型AbOmpA及其对靶向AbOmpA治疗的潜在影响，以便更好地理解AbOmpA，为开发抗鲍曼不动杆菌的新型疗法提供依据。
