Durojaiye Oyewole Christopher, Fiori Charlotte, Cartwright Katharine
Department of Infection and Tropical Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S10 2JF, UK.
OPAT Unit, University Hospitals of Derby and Burton NHS Foundation Trust, Derby DE22 3NE, UK.
Antibiotics (Basel). 2025 Apr 29;14(5):451. doi: 10.3390/antibiotics14050451.
Outpatient parenteral antimicrobial therapy (OPAT) is increasingly used to manage a broad range of infections, enabling patients to receive intravenous antibiotics safely outside inpatient settings. In this review, we examine the current landscape of OPAT practice across the United Kingdom (UK), assessing its clinical, economic, and operational impact. The benefits of OPAT for patients and the National Health Service (NHS), as well as its associated risks, are discussed. Additionally, we explore the challenges hindering its broader implementation within the UK. Finally, we highlight recent innovations and emerging applications of OPAT relevant to the NHS, underscoring key considerations for its future expansion and emphasising the need for a nationally coordinated strategy to realise its full potential.
门诊胃肠外抗菌治疗（OPAT）越来越多地用于管理多种感染，使患者能够在非住院环境中安全地接受静脉抗生素治疗。在本综述中，我们审视了英国门诊胃肠外抗菌治疗（OPAT）的当前实践情况，评估其临床、经济和运营影响。讨论了门诊胃肠外抗菌治疗（OPAT）对患者和国民医疗服务体系（NHS）的益处及其相关风险。此外，我们探讨了阻碍其在英国更广泛实施的挑战。最后，我们强调了与国民医疗服务体系（NHS）相关的门诊胃肠外抗菌治疗（OPAT）的近期创新和新兴应用，强调其未来扩展的关键考虑因素，并强调需要制定全国协调战略以充分发挥其潜力。
