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斯特奇-韦伯综合征中类似中风发作的新诱因:一例报告

New Trigger for Stroke-like Episode in Sturge-Weber Syndrome: A Case Report.

作者信息

Altavilla Emiliano, De Giacomo Andrea, Greco Anna Maria, Tramacere Fernanda, Quarta Marilena, Puscio Daniela, Corsalini Massimo, Pistilli Sara, Sardella Dario, Indrio Flavia

机构信息

Department of Sperimental Medicine Pediatric Section, University of Salento Hospital "Vito Fazzi", 73100 Lecce, Italy.

Department of Child Neuropsychiatry, Policlinico of Bari University Hospital, 70124 Bari, Italy.

出版信息

Children (Basel). 2025 Apr 30;12(5):589. doi: 10.3390/children12050589.

DOI:10.3390/children12050589
PMID:40426769
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12109924/
Abstract

. Sturge-Weber syndrome (SWS) is a rare non-hereditary neurovascular disorder characterized by capillary-venous malformations on the face, ocular vascular anomalies, and leptomeningeal capillary-venous malformations. Patients with SWS often experience cerebral perfusion impairment, increasing their risk for stroke-like episodes, seizures, and motor and cognitive impairments. . We report the case of a 2-year-old boy diagnosed with SWS who developed a stroke-like episode following dye laser therapy under deep sedation. . Despite initial diagnostic challenges and persistent seizures, appropriate management led to full neurological recovery. . This case highlights the importance of considering stroke-like episodes in children with SWS after stressful events such as medical procedures.

摘要

斯特奇-韦伯综合征(SWS)是一种罕见的非遗传性神经血管疾病,其特征为面部毛细血管-静脉畸形、眼部血管异常以及软脑膜毛细血管-静脉畸形。SWS患者常出现脑灌注受损,增加了发生类中风发作、癫痫以及运动和认知障碍的风险。我们报告一例2岁诊断为SWS的男孩,在深度镇静下接受染料激光治疗后发生类中风发作。尽管最初存在诊断挑战且癫痫持续发作,但恰当的治疗使其神经功能完全恢复。该病例强调了对于SWS儿童在诸如医疗操作等应激事件后发生类中风发作的考量的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc6b/12109924/69458e41e057/children-12-00589-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc6b/12109924/69458e41e057/children-12-00589-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc6b/12109924/69458e41e057/children-12-00589-g001.jpg

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本文引用的文献

1
The natural history of pediatric Sturge-Weber Syndrome: A multinational cross-sectional study.小儿斯-韦综合征的自然病史:一项跨国横断面研究。
Eur J Paediatr Neurol. 2025 Jan;54:200-209. doi: 10.1016/j.ejpn.2025.02.004. Epub 2025 Feb 11.
2
Epilepsy surgery in patients with Sturge-Weber Syndrome.患有斯特奇-韦伯综合征患者的癫痫手术
Epilepsy Behav. 2025 Apr;165:110312. doi: 10.1016/j.yebeh.2025.110312. Epub 2025 Feb 19.
3
Innovative use of PreserFlo microshunt in an infant with Sturge-Weber syndrome-related glaucoma: Case report.
PreserFlo微型分流器在一名患有斯特奇-韦伯综合征相关性青光眼婴儿中的创新应用:病例报告。
Int J Surg Case Rep. 2025 Mar;128:111024. doi: 10.1016/j.ijscr.2025.111024. Epub 2025 Feb 6.
4
Transcriptomic Profiling Unveils EDN3 Meningeal Fibroblasts as Key Players in Sturge-Weber Syndrome Pathogenesis.转录组分析揭示内皮素3脑膜成纤维细胞是斯-韦综合征发病机制中的关键因素。
Adv Sci (Weinh). 2025 May;12(17):e2408888. doi: 10.1002/advs.202408888. Epub 2025 Feb 8.
5
Exploring the Efficacy and Safety of Vagus Nerve Stimulation for the Treatment of Epilepsy in Patients With Sturge-Weber Syndrome: A Pilot Study.探索迷走神经刺激术治疗斯-韦综合征患者癫痫的疗效和安全性:一项试点研究。
Pediatr Neurol. 2025 Mar;164:35-40. doi: 10.1016/j.pediatrneurol.2024.12.016. Epub 2025 Jan 3.
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Multidisciplinary, multicenter consensus for the care of patients affected with Sturge-Weber syndrome.关于患有斯-韦综合征患者护理的多学科、多中心共识。
Orphanet J Rare Dis. 2025 Jan 16;20(1):28. doi: 10.1186/s13023-024-03527-w.
7
Sturge-Weber syndrome: updates in translational neurology.斯特奇-韦伯综合征:转化神经学的进展
Front Neurol. 2024 Dec 2;15:1493873. doi: 10.3389/fneur.2024.1493873. eCollection 2024.
8
A Review of Sturge-Weber Syndrome Brain Involvement, Cannabidiol Treatment and Molecular Pathways.《斯特奇-韦伯综合征脑受累的研究进展、大麻二酚治疗及分子通路》
Molecules. 2024 Nov 8;29(22):5279. doi: 10.3390/molecules29225279.
9
Dentistry and Sturge-Weber syndrome: Case report and narrative review.牙科与斯特奇-韦伯综合征:病例报告及综述
Spec Care Dentist. 2025 Jan-Feb;45(1):e13088. doi: 10.1111/scd.13088. Epub 2024 Nov 10.
10
Distribution of Port-Wine Birthmarks and Glaucoma Outcomes in Sturge-Weber Syndrome.斯特奇-韦伯综合征中葡萄酒色斑的分布与青光眼的转归
Ophthalmol Glaucoma. 2025 Mar-Apr;8(2):181-187. doi: 10.1016/j.ogla.2024.10.007. Epub 2024 Oct 22.