Erenas Ondategui Isabel, Gómez Castro Julia, Estepa Hernández Sandra, Chicharro Miguel Celia, Peiró Cárdenas Regina, Fernández-Araque Ana, Verde Zoraida
Faculty of Health Sciences, University of Valladolid, 42004 Soria, Spain.
Department of Nursing, Faculty of Health Sciences, University of Valladolid, 42004 Soria, Spain.
Biomedicines. 2025 May 13;13(5):1183. doi: 10.3390/biomedicines13051183.
: Genetic variants, such as the µ-opioid receptor 1 () and the catechol-O-methyltransferase () , have been considered among the potential causes in the development of some chronic pain conditions. In this regard, there are controversial results regarding their roles in fibromyalgia (FM). We aimed to investigate whether the OPRM1 rs1799971 and COMT rs4680 polymorphisms are associated with the development of or susceptibility to FM, as well as their potential association with syndrome characteristic variables, in a sample of the Spanish population with and without FM. : The present study analysed Val158Met and Asn40Asp genetic variants in 311 FM patients (301 women and 10 men) and 135 non-FM participants (120 women and 15 men). In addition to clinical variables, widespread pain index (WPI), symptom severity scale (SSS) (fatigue, rest quality, and cognitive symptoms), pain, stress episodes, and Borg scale were collected. : The main results indicate that women carrying the Val/Val genotype (i.e., high COMT activity) exhibited significantly lower levels of fatigue, cognitive impairment, and total SSS than heterozygote carriers. In addition, Met allele carriers (i.e., lower COMT activity) showed higher probabilities of suffering a stress episode and higher levels of exertion during daily activities. : The present research suggests a link between dopaminergic dysfunction and exacerbated, frequently described symptoms in female FM patients. Although further research with wider genetic variants and recruited patients is needed, these results point out the necessity of considering gender as a separate category in chronic pain studies.
基因变异，如μ-阿片受体1（OPRM1）和儿茶酚-O-甲基转移酶（COMT），被认为是某些慢性疼痛病症发展的潜在原因之一。在这方面，关于它们在纤维肌痛（FM）中的作用存在有争议的结果。我们旨在调查在西班牙有或没有FM的人群样本中，OPRM1 rs1799971和COMT rs4680多态性是否与FM的发生或易感性相关，以及它们与综合征特征变量的潜在关联。：本研究分析了311名FM患者（301名女性和10名男性）和135名非FM参与者（120名女性和15名男性）中的Val158Met和Asn40Asp基因变异。除了临床变量外，还收集了广泛疼痛指数（WPI）、症状严重程度量表（SSS）（疲劳、休息质量和认知症状）、疼痛、应激事件和博格量表。：主要结果表明，携带Val/Val基因型（即高COMT活性）的女性表现出比杂合子携带者显著更低的疲劳、认知障碍和总SSS水平。此外，Met等位基因携带者（即较低的COMT活性）在日常活动中遭受应激事件的概率更高，且用力水平更高。：本研究表明多巴胺能功能障碍与女性FM患者中加剧的、经常描述的症状之间存在联系。尽管需要对更广泛的基因变异和招募的患者进行进一步研究，但这些结果指出在慢性疼痛研究中需要将性别作为一个单独的类别来考虑。
