Dittmann Philipp, Lehnert Bernhard, Ihler Friedrich, Busch Chia-Jung, Blaurock Markus
Klinik für Mund- Kiefer- Gesichtschirurgie, Plastische Operationen, Universitätsmedizin Greifswald, 17489 Greifswald, Germany.
Klinik für Hals-, Nasen-, Ohrenkrankheiten, Kopf- und Halschirurgie, Universitätsmedizin Greifswald, 17489 Greifswald, Germany.
Biomedicines. 2025 May 20;13(5):1246. doi: 10.3390/biomedicines13051246.
The various head and neck squamous cell carcinoma (HNSCC) subtypes are among the most common cancers globally, with significant recurrence rates within the first two years post-treatment. Despite advancements in treatment, structured early follow-up remains crucial for timely diagnosis and effective salvage treatment. : This retrospective study examines the impact of implementing a structured initial restaging between three and six months after the conclusion of initial treatment. The study population included 532 patients treated with curative intent at the University Medicine of Greifswald, Germany, between 2010 and 2019. Patients were divided into two groups: standard follow-up (SF) and adapted follow-up (AF). The AF group received standardized post-treatment restaging, including imaging and panendoscopy or PET-CT exams. : We found a trend towards earlier diagnosis and a reduction in recurrences, although these differences were not statistically significant. Secondary cancers were observed more frequently in the AF group, significantly affecting overall survival. : Our cohort supports structured initial cancer follow-up in HNSCC. Although not significant, an initial multimodal exam after treatment was well tolerated and showed a trend toward earlier diagnosis.
各种头颈鳞状细胞癌（HNSCC）亚型是全球最常见的癌症之一，在治疗后的头两年内复发率很高。尽管治疗取得了进展，但结构化的早期随访对于及时诊断和有效的挽救治疗仍然至关重要。本回顾性研究探讨了在初始治疗结束后三到六个月进行结构化初始再分期的影响。研究人群包括2010年至2019年期间在德国格赖夫斯瓦尔德大学医学中心接受根治性治疗的532例患者。患者分为两组：标准随访（SF）组和适应性随访（AF）组。AF组接受标准化的治疗后再分期，包括影像学检查和全内镜检查或PET-CT检查。我们发现有早期诊断的趋势以及复发率降低，尽管这些差异无统计学意义。AF组中继发性癌症的观察更为频繁，显著影响总体生存率。我们的队列研究支持HNSCC的结构化初始癌症随访。尽管不显著，但治疗后的初始多模式检查耐受性良好，并显示出早期诊断的趋势。
