Rubin L J
Chest. 1985 Oct;88(4 Suppl):257S-260S. doi: 10.1378/chest.88.4_supplement.257s.
The demonstration that the calcium channel blockers reduce pulmonary vasomotor tone in experimental models of pulmonary hypertension has served as the rationale for their use in the management of primary pulmonary hypertension. The three currently available agents, verapamil, nifedipine, and diltiazem, have varying degrees of pulmonary vasoactivity. Experience with their use is reviewed.
钙通道阻滞剂可降低肺动脉高压实验模型中的肺血管收缩张力，这一发现为其用于原发性肺动脉高压的治疗提供了理论依据。目前可用的三种药物，维拉帕米、硝苯地平和地尔硫䓬，具有不同程度的肺血管活性。本文对它们的使用经验进行了综述。
