Packer M
Chest. 1985 Oct;88(4 Suppl):265S-268S.
Despite isolated reports of dramatic hemodynamic and clinical improvement over the past 30 years, most patients with primary pulmonary hypertension fail to benefit from treatment with vasodilator drugs and many develop serious adverse reactions. The failure of this approach strongly suggests that pulmonary vasoconstriction does not play an important role in the pathogenesis of this disorder.
尽管在过去30年中有个别报道称患者的血流动力学和临床症状有显著改善，但大多数原发性肺动脉高压患者未能从血管扩张剂治疗中获益，许多患者还出现了严重的不良反应。这种治疗方法的失败有力地表明，肺血管收缩在这种疾病的发病机制中并不起重要作用。
