Narfström K, Nilsson S E
Doc Ophthalmol. 1985 Aug 30;60(2):183-7. doi: 10.1007/BF00158033.
Ophthalmoscopic and electroretinographic (ERG) findings were correlated in a group of Abyssinian cats affected by a slowly progressive and hereditary retinal degenerative disease. According to ophthalmoscopic findings the disease was divided into stages. At stage 1 and 2 retinal changes were minor; showing a gray discoloration most often in the peripheral and midperipheral tapetal fundus. At stage 3 discoloration was generalized and there was marked vascular attenuation. A generalized retinal atrophy was found at stage 4. ERG recordings showed an abnormally depressed stimulus response curve for the b-wave at stage 1 of disease when 30-Hz cone flicker responses were indistinguishable from normal. With progression of disease there was a successive decrease of a- and b-wave amplitudes before there was a significant reduction also of the c-wave amplitude (first seen at stage 3). The ERG was nonrecordable at stage 4. These findings suggest that the photoreceptors are affected primarily by the disease, before there is a functional involvement also of the pigment epithelium. The rod system seems to be affected early in the disease as compared with the cone system. A staging of the disease by ophthalmoscopy correlated more to the function of the rods than to that of the cones.
在一组患有缓慢进展性遗传性视网膜退行性疾病的阿比西尼亚猫中，对检眼镜检查结果和视网膜电图（ERG）结果进行了相关性分析。根据检眼镜检查结果，将该疾病分为不同阶段。在第1阶段和第2阶段，视网膜变化较小；最常见的表现是在周边和中周边的反光眼底出现灰色变色。在第3阶段，变色变得普遍，并且存在明显的血管变细。在第4阶段发现了广泛性视网膜萎缩。ERG记录显示，在疾病的第1阶段，当30赫兹锥体闪烁反应与正常反应无法区分时，b波的刺激反应曲线异常压低。随着疾病的进展，在c波振幅也显著降低（首次出现在第3阶段）之前，a波和b波振幅相继下降。在第4阶段，ERG无法记录。这些发现表明，在色素上皮也出现功能受累之前，光感受器首先受到该疾病的影响。与锥体系统相比，杆体系统似乎在疾病早期就受到影响。通过检眼镜检查对疾病进行分期，与杆体的功能相关性比对锥体功能的相关性更大。
