Koceva Andrijana, Janež Andrej, Jensterle Mojca
Department of Endocrinology and Diabetology, Clinic of Internal Medicine, University Medical Center Maribor, 2000 Maribor, Slovenia.
Faculty of Medicine, University of Maribor, 2000 Maribor, Slovenia.
Medicina (Kaunas). 2025 May 1;61(5):838. doi: 10.3390/medicina61050838.
Arginine-vasopressin peptide (AVP) plays a critical role in water balance and osmoregulation. However, emerging evidence suggests that AVP's actions may expand beyond its traditional role, significantly influencing metabolic regulation, including glucose homeostasis, insulin sensitivity, lipid metabolism and energy balance. Elevated AVP levels are seen in various metabolic conditions, such as insulin resistance, metabolic syndrome, type 2 diabetes (T2D) and obesity, further highlighting its potential role as a metabolic regulator. As AVP levels are regulated by hydration status, studies have proposed that chronic hypohydration and persistently elevated AVP levels may contribute to metabolic dysfunction, where increased hydration and therefore AVP suppression may lead to potential metabolic improvements. By analyzing data from animal studies, human observational research and interventional trials, this review evaluates the current evidence on the potential causal relationships and impact of AVP on metabolic regulation, as well as exploring the role of hydration in AVP-mediated metabolic outcomes.
精氨酸加压素（AVP）在水平衡和渗透压调节中起关键作用。然而，新出现的证据表明，AVP的作用可能超出其传统作用，对代谢调节产生重大影响，包括葡萄糖稳态、胰岛素敏感性、脂质代谢和能量平衡。在各种代谢状况下，如胰岛素抵抗、代谢综合征、2型糖尿病（T2D）和肥胖症中，都可见到AVP水平升高，这进一步凸显了其作为代谢调节因子的潜在作用。由于AVP水平受水合状态调节，研究表明，慢性脱水和持续升高的AVP水平可能导致代谢功能障碍，而增加水合作用从而抑制AVP可能带来潜在的代谢改善。通过分析动物研究、人体观察性研究和干预试验的数据，本综述评估了关于AVP对代谢调节的潜在因果关系和影响的现有证据，并探讨了水合作用在AVP介导的代谢结果中的作用。
