Haas R, Mundinger A, Bohn T, Schaz K, Hunstein W
Dtsch Med Wochenschr. 1985 Oct 11;110(41):1573-6. doi: 10.1055/s-2008-1069049.
In two of four patients with hypereosinophilia and Löffler's myocarditis (confirmed by biopsy) the activity of the disease was contained with prednisone, in one instance combined with hydroxycarbamide. In two patients, in whom the disease was taking a fulminant course and other treatment had failed, cytarabine and 6-thioguanine proved effective, providing a 16-month symptom-free period in one of them. But the second patient died from septicaemia associated with treatment-induced bone-marrow hypoplasia. Prednisone (1 mg/kg daily) and hydroxycarbamide (0.5-1.5 g daily) are the drugs of choice in the hypereosinophilia syndrome. If they fail, cytarabine (100 mg/m2 on days 1-5, repeated on day 28) and 6-thioguanine (100 mg/m2 daily) should be given.
在4例嗜酸性粒细胞增多症合并吕弗勒心肌炎（经活检确诊）患者中，有2例患者的病情活动通过泼尼松得到控制，其中1例联合使用了羟基脲。在2例病情呈暴发性且其他治疗失败的患者中，阿糖胞苷和6-硫鸟嘌呤被证明有效，其中1例患者获得了16个月的无症状期。但第2例患者死于与治疗引起的骨髓发育不全相关的败血症。泼尼松（每日1 mg/kg）和羟基脲（每日0.5 - 1.5 g）是嗜酸性粒细胞增多综合征的首选药物。如果它们治疗失败，应给予阿糖胞苷（第1 - 5天100 mg/m²，第28天重复）和6-硫鸟嘌呤（每日100 mg/m²）。
