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颌面脓肿行口外引流患者术后并发症的发生率及危险因素:一项回顾性队列研究

Incidence and Risk Factors for Postoperative Complications in Patients Undergoing Extraoral Drainage for Maxillofacial Abscess: A Retrospective Cohort Study.

作者信息

Longchamp Gregoire, Essig Harald, Dirr Valerian, Precht Marc M, Wagner Maximilian E H, Ferrari Raphael

机构信息

Department of Cranio-Maxillofacial and Oral Surgery, University Hospital of Zurich, 8091 Zurich, Switzerland.

出版信息

J Clin Med. 2025 May 12;14(10):3368. doi: 10.3390/jcm14103368.

Abstract

The standard treatment for maxillofacial abscesses is surgical drainage combined with antibiotics, a frequent procedure in maxillofacial surgery departments. However, postoperative complications following this surgery are poorly described in the literature. Identifying their incidence and risk factors could help improve patient outcomes and healthcare planning. The primary aim was to identify postoperative complications within 30 days after maxillofacial abscess surgery; the secondary aim was to explore their associated risk factors. A monocentric retrospective cohort study included patients with maxillofacial abscesses who underwent extraoral incision and drainage under general anesthesia at the Department of Cranio-Maxillofacial and Oral Surgery at a tertiary hospital in Switzerland between January 2012 and August 2023. Postoperative complications within 30 days were recorded and classified according to the validated Dindo-Clavien classification system. Univariable and multivariable logistic regression analyses were conducted to identify risk factors for postoperative complications. A total of 253 participants were analyzed. The overall complication rate was 24.1%, with 15.8% major complications (Dindo-Clavien grade ≥ 3). The most common minor complications (Dindo-Clavien grade < 3) were hypokalemia and lower-extremity edema, with an incidence of 6.4%. The most common major complications were persistent and recurrent abscesses, with an incidence rate of 10.4%. These complications occurred in the early (median range 1-5 days) and delayed (median range 14-15 days) postoperative courses, respectively. Overall, the mortality rate was 0.4%. On multivariable analysis, an American Society of Anesthesiologists (ASA) score > 2 was associated with overall and major postoperative complications (odds ratio [OR], 3.38; 95% CI 1.75-6.51; < 0.001 and OR, 3.76; 95% CI 1.83-7.72; < 0.001, respectively). Additionally, female sex (OR, 1.97; 95% CI 1.05-3.70; = 0.036) and C-reactive protein level > 50 mg/L (OR, 2.25; 95% CI 1.01-4.98; = 0.046) were associated with overall postoperative complications. This study introduces a novel application of the Dindo-Clavien classification to maxillofacial abscess surgery, providing a standardized framework for assessing postoperative complication severity. Through this approach, we identified ASA score > 2, female sex, and CRP level > 50 mg/L as risk factors for postoperative complications. Our findings highlight the importance of close monitoring during the first five postoperative days to detect early complications, such as persistent abscesses, and recommend standardized outpatient follow-up for at least two weeks to identify delayed complications, like recurrence.

摘要

颌面部脓肿的标准治疗方法是手术引流联合使用抗生素,这在颌面外科科室是一种常见的操作。然而,该手术的术后并发症在文献中描述较少。确定其发生率和风险因素有助于改善患者预后和医疗规划。主要目的是确定颌面部脓肿手术后30天内的术后并发症;次要目的是探讨其相关风险因素。一项单中心回顾性队列研究纳入了2012年1月至2023年8月期间在瑞士一家三级医院的颅颌面与口腔外科接受全身麻醉下口外切开引流的颌面部脓肿患者。记录30天内的术后并发症,并根据经过验证的Dindo-Clavien分类系统进行分类。进行单变量和多变量逻辑回归分析以确定术后并发症的风险因素。共分析了253名参与者。总体并发症发生率为24.1%,其中15.8%为严重并发症(Dindo-Clavien分级≥3级)。最常见的轻微并发症(Dindo-Clavien分级<3级)是低钾血症和下肢水肿,发生率为6.4%。最常见的严重并发症是持续性和复发性脓肿,发生率为10.4%。这些并发症分别发生在术后早期(中位时间范围为1 - 5天)和延迟期(中位时间范围为14 - 15天)。总体死亡率为0.4%。多变量分析显示,美国麻醉医师协会(ASA)评分>2与总体和严重术后并发症相关(比值比[OR],3.38;95%置信区间1.75 - 6.51;P<0.001和OR,3.76;95%置信区间1.83 - 7.72;P<0.001)。此外,女性(OR,1.97;95%置信区间1.05 - 3.70;P = 0.036)和C反应蛋白水平>50 mg/L(OR,2.25;95%置信区间1.01 - 4.98;P = 0.046)与总体术后并发症相关。本研究将Dindo-Clavien分类法创新性地应用于颌面部脓肿手术,为评估术后并发症严重程度提供了标准化框架。通过这种方法,我们确定ASA评分>2、女性以及CRP水平>50 mg/L为术后并发症的风险因素。我们的研究结果强调了术后前五天密切监测以发现早期并发症(如持续性脓肿)的重要性,并建议进行至少两周时间的标准化门诊随访以识别延迟并发症(如复发)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13f6/12111953/7788e93e7cc4/jcm-14-03368-g001.jpg

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