触珠蛋白在化脓性汗腺炎皮肤病变中的免疫组化表达

Immunohistochemical Expression of Haptoglobin in Skin Lesions of Hidradenitis Suppurativa.

作者信息

Abu Rached Nessr, Telkemeyer Hanna, Skrygan Marina, Doerler Martin, Haven Yannik, Ocker Lennart, Myszkowski Daniel, Meyer Thomas, Stücker Markus, Stockfleth Eggert, Bechara Falk G

机构信息

International Centre for Hidradenitis Suppurativa/Acne Inversa (ICH), Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, Germany.

Skin Cancer Center, Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, Germany.

出版信息

Life (Basel). 2025 May 2;15(5):738. doi: 10.3390/life15050738.

DOI:10.3390/life15050738

PMID:40430166

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12113320/

Abstract

BACKGROUND

Meta-inflammation is a hallmark of hidradenitis suppurativa (HS). Research on meta-inflammation in HS is growing, but there is still no research on haptoglobin as an inflammatory protein in lesional HS skin. This study examines the relationship between haptoglobin expression in HS skin lesions and clinical parameters.

METHODS

An examination was performed on 44 skin samples from HS patients and 10 healthy skin samples. Clinical parameters were then compared with haptoglobin expression.

RESULTS

Median haptoglobin expression was significantly higher in the Hurley stage III lesions compared with milder stages (H-score: 37.6 versus 17.1, = 0.028). High haptoglobin expression (≥30.8% positive cells) was associated with advanced disease (Hurley stage III: 80% versus 41.7%, = 0.01), active smoking (80% versus 50%, = 0.039), increased pain (visual analogue scale: 5 versus 1.5, = 0.03), and a higher prevalence of diabetes (35% versus 8.3%, = 0.029) and hypertension (55% versus 25%, = 0.042). No significant associations were found with the BMI, disease duration, or CRP levels.

CONCLUSIONS

High haptoglobin expression (positive cells ≥ 30.8%) in a skin lesion is associated with higher HS severity, active smoking, more pain and the comorbidities of diabetes mellitus and arterial hypertension in HS patients.

摘要

背景

间质性炎症是化脓性汗腺炎（HS）的一个标志。关于HS中间质性炎症的研究正在增加，但仍没有关于结合珠蛋白作为HS皮损中一种炎症蛋白的研究。本研究探讨HS皮肤病变中结合珠蛋白表达与临床参数之间的关系。

方法

对44例HS患者的皮肤样本和10例健康皮肤样本进行检测。然后将临床参数与结合珠蛋白表达进行比较。

结果

与较轻阶段相比，Hurley III期病变中的结合珠蛋白表达中位数显著更高（H评分：37.6对17.1，P = 0.028）。高结合珠蛋白表达（≥30.8%阳性细胞）与疾病进展（Hurley III期：80%对41.7%，P = 0.01）、当前吸烟（80%对50%，P = 0.039）、疼痛增加（视觉模拟评分：5对1.5，P = 0.03）以及糖尿病（35%对8.3%，P = 0.029）和高血压（55%对25%，P = 0.042）的较高患病率相关。未发现与BMI、病程或CRP水平有显著关联。