Hahn Robert G
Department of Clinical Sciences at Danderyd Hospital, Karolinska Institutet, 182 88 Stockholm, Sweden.
Life (Basel). 2025 May 7;15(5):749. doi: 10.3390/life15050749.
Low-frequency oscillations of blood components have been observed when the plasma is diluted by crystalloid fluid. The present study explores whether oscillations also occur during the infusion of hyper-oncotic albumin 20%. For this purpose, the hemoglobin-derived plasma dilution, plasma colloid osmotic pressure, and plasma albumin concentration were measured on 15 occasions over 5 h in 72 volunteers. All of them received 3 mL/kg of albumin 20% over 30 min in various clinical settings. Quality checks excluded 35% of the concentration-time curves, leaving 137 for analysis. Fourier transforms applied to the residuals after curve-fitting showed that the dominating frequency was 144 ± 42 min (mean ± SD), corresponding to 0.007 Hz and a wave amplitude of 1.8 ± 0.9%. The highest percentile of the amplitudes corresponded to a "peak-to-peak" variation in the plasma volume by 6%, which corresponds to a fluctuation of 180 mL, or 45% of the maximum volume expansion following the infusion of albumin 20%. Differences between settings (volunteers, surgery, postoperative, and post-burn) were small. In conclusion, oscillations with very low frequency occurred after infusion of albumin 20%. They varied the plasma volume by 3.6% and by up to 6% in the percentile with the highest amplitudes. The oscillations are large enough to affect measurements of cardiovascular function.
当血浆被晶体液稀释时，已观察到血液成分的低频振荡。本研究探讨在输注20%高渗白蛋白期间是否也会发生振荡。为此，在72名志愿者中，于5小时内分15次测量了血红蛋白衍生的血浆稀释度、血浆胶体渗透压和血浆白蛋白浓度。他们所有人在各种临床环境下，于30分钟内接受了3 mL/kg的20%白蛋白输注。质量检查排除了35%的浓度-时间曲线，剩余137条用于分析。对曲线拟合后的残差进行傅里叶变换显示，主导频率为144±42分钟（均值±标准差），对应于0.007 Hz，波幅为1.8±0.9%。振幅的最高百分位数对应血浆体积“峰-峰”变化6%，这相当于180 mL的波动，或相当于输注20%白蛋白后最大体积扩张的45%。不同设置（志愿者、手术、术后和烧伤后）之间的差异很小。总之，输注20%白蛋白后出现了极低频率的振荡。它们使血浆体积变化了3.6%，在振幅最高的百分位数中变化高达6%。这些振荡足以影响心血管功能的测量。
