Lal Hind, Verma Suresh Kumar, Wang Yajing, Xie Min, Young Martin E
Division of Cardiovascular Disease, Department of Medicine (H.L., S.K.V., M.X., M.E.Y.), University of Alabama at Birmingham.
Department of Biomedical Engineering (Y.W.), University of Alabama at Birmingham.
Circ Res. 2024 Mar 15;134(6):635-658. doi: 10.1161/CIRCRESAHA.123.323520. Epub 2024 Mar 14.
Energetic demand and nutrient supply fluctuate as a function of time-of-day, in alignment with sleep-wake and fasting-feeding cycles. These daily rhythms are mirrored by 24-hour oscillations in numerous cardiovascular functional parameters, including blood pressure, heart rate, and myocardial contractility. It is, therefore, not surprising that metabolic processes also fluctuate over the course of the day, to ensure temporal needs for ATP, building blocks, and metabolism-based signaling molecules are met. What has become increasingly clear is that in addition to classic signal-response coupling (termed reactionary mechanisms), cardiovascular-relevant cells use autonomous circadian clocks to temporally orchestrate metabolic pathways in preparation for predicted stimuli/stresses (termed anticipatory mechanisms). Here, we review current knowledge regarding circadian regulation of metabolism, how metabolic rhythms are synchronized with cardiovascular function, and whether circadian misalignment/disruption of metabolic processes contribute toward the pathogenesis of cardiovascular disease.
能量需求和营养供应会随着一天中的时间而波动，与睡眠-觉醒和禁食-进食周期相一致。这些每日节律反映在众多心血管功能参数的24小时振荡中，包括血压、心率和心肌收缩力。因此，代谢过程在一天中也会波动，以确保满足对三磷酸腺苷（ATP）、构建模块和基于代谢的信号分子的时间需求，这并不奇怪。越来越清楚的是，除了经典的信号-反应偶联（称为反应机制）外，与心血管相关的细胞还利用自主生物钟在时间上协调代谢途径，为预测的刺激/应激做好准备（称为预期机制）。在这里，我们综述了关于代谢的昼夜节律调节、代谢节律如何与心血管功能同步以及代谢过程的昼夜失调是否导致心血管疾病发病机制的现有知识。
