肠道微生物群作为预防卵清蛋白诱导的食物过敏的靶点。
Gut Microbiota as Targets for Preventing Ovalbumin-Induced Food Allergy.
作者信息
Shi Xiaolei, Liu Huimin, Zhang Jiayin, Yu Yawen, Xiao Jing, Matsui Katsuhiko, Li Xuwen, Jin Yongri
机构信息
College of Food Science and Engineering, Jilin University, Changchun 130062, China.
State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130012, China.
出版信息
Nutrients. 2025 May 8;17(10):1611. doi: 10.3390/nu17101611.
BACKGROUND
Ovalbumin (OVA) is a major allergen in egg whites.
INTRODUCTION
Given the crucial role of gut microbiota in OVA-induced allergy, it remains unclear whether gut microbiota could serve as a therapeutic target for OVA allergy prevention.
METHOD
To investigate the relationship between gut microbiota and food allergy, a two-sample bidirectional Mendelian randomization approach was combined combined with gut microbiota diversity analysis in vivo. Statistical analysis was performed, with < 0.05 considered statistically significant and < 0.01 highly significant.
RESULTS AND DISCUSSION
Notably, represents a potential therapeutic target for food allergy intervention, but the discrepancy between the MR and experimental findings highlights the limitations of the current research. When targeting the genus , we observed that narirutin administration increased the abundance of the family and the genus .
CONCLUSIONS
Narirutin may exert protective effects by increasing abundance, but its precise mechanism-particularly whether it depends on SCFAs-requires further investigation.
背景
卵清蛋白（OVA）是蛋清中的主要过敏原。
引言
鉴于肠道微生物群在OVA诱导的过敏中起关键作用，肠道微生物群是否可作为预防OVA过敏的治疗靶点仍不清楚。
方法
为研究肠道微生物群与食物过敏之间的关系，采用两样本双向孟德尔随机化方法并结合体内肠道微生物群多样性分析。进行了统计分析，P<0.05被认为具有统计学意义，P<0.01具有高度统计学意义。
结果与讨论
值得注意的是，[此处原文有缺失内容]代表食物过敏干预的潜在治疗靶点，但孟德尔随机化（MR）与实验结果之间的差异凸显了当前研究的局限性。当针对[此处原文有缺失内容]属时，我们观察到橙皮素给药增加了[此处原文有缺失内容]科和[此处原文有缺失内容]属的丰度。
结论
橙皮素可能通过增加[此处原文有缺失内容]丰度发挥保护作用，但其确切机制——特别是它是否依赖于短链脂肪酸——需要进一步研究。
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