Wang Yuqian, Han Rui, Ling Changquan
School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Department of Traditional Chinese Medicine Oncology, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China.
Vaccines (Basel). 2025 May 9;13(5):502. doi: 10.3390/vaccines13050502.
This Letter to the Editor explores synergistic mechanisms enhancing mRNA cancer vaccine efficacy through bile acid metabolism modulation in liver cancer treatment. The latest evidence indicates that bile acids significantly impair T cell function within the liver cancer microenvironment, creating an immunosuppressive milieu that hampers anti-tumor responses. Modulating bile acid composition, particularly increasing ursodeoxycholic acid (UDCA), could reshape the tumor microenvironment (TME) to favor mRNA vaccine-induced T cell activity-a promising strategy to overcome current immunotherapy limitations in liver cancer.
这封致编辑的信探讨了在肝癌治疗中通过调节胆汁酸代谢增强mRNA癌症疫苗疗效的协同机制。最新证据表明，胆汁酸会显著损害肝癌微环境中的T细胞功能，营造出一种抑制抗肿瘤反应的免疫抑制环境。调节胆汁酸组成，特别是增加熊去氧胆酸（UDCA），可以重塑肿瘤微环境（TME），以利于mRNA疫苗诱导的T细胞活性——这是一种克服当前肝癌免疫治疗局限性的有前景的策略。
