Drymonitou Georgia, McCulloch Amy, Parry Sarah, Gough Rhia, Moreira Cruz Rodrigo, Mostoufi Mia, Jawad Mariam, Newman Charlotte, Harding Duncan, Salazar de Pablo Gonzalo, Jewell Tom
Oxford Health NHS Foundation Trust, Oxford, UK.
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Psychol Med. 2025 May 28;55:e160. doi: 10.1017/S003329172500114X.
Eating disorders and psychotic disorders represent two of the most serious psychiatric conditions. Emerging lines of evidence from genetic and epidemiological studies suggest that these disorders may commonly co-occur. This systematic review investigated the association between these disorders across community and clinical populations.
A systematic review was preregistered (CRD42021231771) and conducted according to PRISMA guidelines. Web of Science, PsycINFO and Medline were searched for articles on the association and comorbidity between psychosis and eating disorders up to the 26th February 2024. A random effects meta-analysis was conducted for studies reporting comorbidity of eating disorders and psychotic disorders based on clinical diagnosis or interview measures, to estimate prevalence of the comorbidity between these disorders. A narrative synthesis was conducted for all other studies and grouped by sample (general population, eating disorders or psychotic disorders).
In total 43 studies met inclusion criteria for the systematic review and 16 were included in the meta-analysis. Findings suggest substantial comorbidity between eating disorders and psychotic disorders, with a pooled comorbidity prevalence of 8% (CI: 3, 14) based on clinical diagnosis or interview measures. Studies using self-report questionnaires also highlight the association between eating disorders and psychosis across clinical and community populations.
Eating disorders and psychotic disorders frequently co-occur. Further research should investigate the temporal order of symptom development and consider the need for novel interventions targeted at overlapping psychotic and eating disorder symptoms and associated phenomena.
饮食失调和精神障碍是两种最严重的精神疾病。遗传和流行病学研究中不断出现的证据表明，这些疾病可能经常同时发生。本系统评价调查了社区和临床人群中这些疾病之间的关联。
一项系统评价预先注册（CRD42021231771）并按照PRISMA指南进行。检索了Web of Science、PsycINFO和Medline，以查找截至2024年2月26日关于精神病与饮食失调之间关联和共病的文章。对基于临床诊断或访谈测量报告饮食失调和精神障碍共病的研究进行随机效应荟萃分析，以估计这些疾病之间共病的患病率。对所有其他研究进行叙述性综合，并按样本（一般人群、饮食失调或精神障碍）分组。
共有43项研究符合系统评价的纳入标准，16项纳入荟萃分析。研究结果表明饮食失调和精神障碍之间存在大量共病，基于临床诊断或访谈测量的合并共病患病率为8%（CI：3，14）。使用自我报告问卷的研究也强调了临床和社区人群中饮食失调与精神病之间存在关联。
饮食失调和精神障碍经常同时发生。进一步的研究应调查症状发展的时间顺序，并考虑是否需要针对重叠的精神病和饮食失调症状及相关现象的新型干预措施。
Zotero 插件