Kapiszewska M, Szumiel I, Wlodek D
Exp Cell Res. 1985 Sep;160(1):236-9. doi: 10.1016/0014-4827(85)90252-6.
Heating L5178Y cells for 15 min at 43 degrees C caused a decrease in [3H]thymidine incorporation, which could be reversed by post-treatment with 0.75 mM caffeine in an L5178Y-S (radiation-sensitive, heat-resistant) but not in an L5178Y-R (radiation-resistant, heat-sensitive) strain. The reversal was accompanied by a sparing effect of the treatment: survival of L5178Y-S cells increased by a factor of 1.5. The effect of combined (heat + caffeine) treatment of L5178Y-R cells was cumulative.
将L5178Y细胞在43摄氏度下加热15分钟会导致[3H]胸苷掺入量减少，在L5178Y-S（辐射敏感、耐热）细胞系中，用0.75 mM咖啡因进行后处理可逆转这种情况，但在L5178Y-R（辐射抗性、热敏）细胞系中则不能。这种逆转伴随着处理的保护作用：L5178Y-S细胞的存活率提高了1.5倍。L5178Y-R细胞联合（加热+咖啡因）处理的效果是累积性的。
