• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

水稻白叶枯病菌的转录激活样效应因子通过OsWRKYs劫持宿主转录调控。

Transcription activator-like effectors of Xanthomonas oryzae pv. oryzae hijack host transcriptional regulation through OsWRKYs.

作者信息

Im Jong Hee, Choi Naeyeoung, Lee Jinjeong, Jung Man-Young, Park Sang Ryeol, Hwang Duk-Ju

机构信息

National Institute of Agricultural Sciences, Rural Development Administration, Jeonju, 54874, Korea.

Interdisciplinary Graduate Programme in Advanced Convergence Technology and Science, Jeju National University, 102 Jejudaehak-ro, Jeju, 63243, Korea.

出版信息

J Integr Plant Biol. 2025 Aug;67(8):2198-2213. doi: 10.1111/jipb.13940. Epub 2025 May 28.

DOI:10.1111/jipb.13940
PMID:40432507
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12315496/
Abstract

Transcription activator-like effectors (TALEs) mimic eukaryotic transcriptional activators and translocate into host plant cells via the bacterial type III secretion system (T3SS) during pathogenic interactions. They play a crucial role in disease development by regulating host genes. Despite this, the regulatory mechanisms by which TALEs control OsWRKY transcription factors (TFs) remain poorly understood. In this study, we show that two TALEs from Xanthomonas oryzae pv. oryzae (Xoo) individually modulate two OsWRKY TFs, resulting in increased susceptibility and reduced host defense. Specifically, Xoo1219 and Xoo2145 activate the expression of OsWRKY104 and OsWRKY55, respectively, through direct interactions. OsWRKY104 increases the susceptibility to Xoo by activating OsSWEET11 and OsSWEET14, while OsWRKY55 suppresses host defense against Xoo by directly regulating OsWRKY62. These findings suggest that TALEs hijack the host's OsWRKY TFs to create a favorable environment for bacterial survival.

摘要

转录激活样效应因子（TALEs）模拟真核转录激活因子，并在致病相互作用期间通过细菌III型分泌系统（T3SS）转运到宿主植物细胞中。它们通过调控宿主基因在疾病发展中发挥关键作用。尽管如此，TALEs调控OsWRKY转录因子（TFs）的机制仍知之甚少。在本研究中，我们表明来自水稻白叶枯病菌（Xanthomonas oryzae pv. oryzae，Xoo）的两个TALEs分别调节两个OsWRKY TFs，导致易感性增加和宿主防御能力降低。具体而言，Xoo1219和Xoo2145分别通过直接相互作用激活OsWRKY104和OsWRKY55的表达。OsWRKY104通过激活OsSWEET11和OsSWEET14增加对Xoo的易感性，而OsWRKY55通过直接调节OsWRKY62抑制宿主对Xoo的防御。这些发现表明，TALEs劫持宿主的OsWRKY TFs以创造有利于细菌生存的环境。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d820/12315496/eba871782e9d/JIPB-67-2198-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d820/12315496/59e65dc00919/JIPB-67-2198-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d820/12315496/3dcc29610210/JIPB-67-2198-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d820/12315496/0cd32649dac4/JIPB-67-2198-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d820/12315496/321d9a701a1e/JIPB-67-2198-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d820/12315496/5d1128b56d77/JIPB-67-2198-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d820/12315496/e56d0f145dfb/JIPB-67-2198-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d820/12315496/6d0086927f71/JIPB-67-2198-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d820/12315496/eba871782e9d/JIPB-67-2198-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d820/12315496/59e65dc00919/JIPB-67-2198-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d820/12315496/3dcc29610210/JIPB-67-2198-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d820/12315496/0cd32649dac4/JIPB-67-2198-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d820/12315496/321d9a701a1e/JIPB-67-2198-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d820/12315496/5d1128b56d77/JIPB-67-2198-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d820/12315496/e56d0f145dfb/JIPB-67-2198-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d820/12315496/6d0086927f71/JIPB-67-2198-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d820/12315496/eba871782e9d/JIPB-67-2198-g002.jpg

相似文献

1
Transcription activator-like effectors of Xanthomonas oryzae pv. oryzae hijack host transcriptional regulation through OsWRKYs.水稻白叶枯病菌的转录激活样效应因子通过OsWRKYs劫持宿主转录调控。
J Integr Plant Biol. 2025 Aug;67(8):2198-2213. doi: 10.1111/jipb.13940. Epub 2025 May 28.
2
Functional analysis of African Xanthomonas oryzae pv. oryzae TALomes reveals a new susceptibility gene in bacterial leaf blight of rice.非洲稻黄单胞菌 TALome 的功能分析揭示了水稻细菌性条斑病的一个新的感病基因。
PLoS Pathog. 2018 Jun 4;14(6):e1007092. doi: 10.1371/journal.ppat.1007092. eCollection 2018 Jun.
3
Five phylogenetically close rice SWEET genes confer TAL effector-mediated susceptibility to Xanthomonas oryzae pv. oryzae.五个系统发育上相近的水稻 SWEET 基因赋予了对稻黄单胞菌 pv. 稻致病变种的 TAL 效应子介导的易感性。
New Phytol. 2013 Nov;200(3):808-819. doi: 10.1111/nph.12411. Epub 2013 Jul 24.
4
The Rice Locus Is a Bidirectional Target of the African pv. Major Transcription Activator-like Effector TalC but Does Not Contribute to Disease Susceptibility.水稻基因座是非洲 pv. 主要转录激活子样效应因子 TalC 的双向靶标，但不影响疾病易感性。
Int J Mol Sci. 2022 May 16;23(10):5559. doi: 10.3390/ijms23105559.
5
Overexpression of gene increases the rice resistance to pv. through negatively regulating transcription activator-like effectors translocation.基因的过表达通过负向调节转录激活样效应因子的易位来提高水稻对[病原菌名称]的抗性。 （注：原文中“pv.”后应有具体病原菌名称未给出，这里以[病原菌名称]表示）
Plant Signal Behav. 2025 Dec;20(1):2441864. doi: 10.1080/15592324.2024.2441864. Epub 2024 Dec 24.
6
The host basal transcription factor IIA subunits coordinate for facilitating infection of TALEs-carrying bacterial pathogens in rice.宿主基础转录因子 IIA 亚基协调促进携带 TALEs 的细菌病原体在水稻中的感染。
Plant Sci. 2019 Jul;284:48-56. doi: 10.1016/j.plantsci.2019.04.004. Epub 2019 Apr 6.
7
A knowledge-based molecular screen uncovers a broad-spectrum OsSWEET14 resistance allele to bacterial blight from wild rice.基于知识的分子筛选从野生稻中发现了一种对白叶枯病具有广谱抗性的OsSWEET14等位基因。
Plant J. 2015 Nov;84(4):694-703. doi: 10.1111/tpj.13042.
8
A transcription activator-like effector from Xanthomonas oryzae pv. oryzicola elicits dose-dependent resistance in rice.来自水稻细菌性条斑病菌的一种转录激活样效应因子在水稻中引发剂量依赖性抗性。
Mol Plant Pathol. 2017 Jan;18(1):55-66. doi: 10.1111/mpp.12377. Epub 2016 Apr 21.
9
Transcription activator-like (TAL) effectors targeting OsSWEET genes enhance virulence on diverse rice (Oryza sativa) varieties when expressed individually in a TAL effector-deficient strain of Xanthomonas oryzae.转录激活子样效应物（TAL）靶向 OsSWEET 基因，当在缺乏 TAL 效应物的稻黄单胞菌菌株中单独表达时，可增强对不同水稻（Oryza sativa）品种的致病性。
New Phytol. 2012 Dec;196(4):1197-1207. doi: 10.1111/j.1469-8137.2012.04367.x. Epub 2012 Oct 18.
10
Xanthomonas oryzae pv. oryzae TALE proteins recruit OsTFIIAγ1 to compensate for the absence of OsTFIIAγ5 in bacterial blight in rice.稻黄单胞菌叶斑病菌 TALE 蛋白招募 OsTFIIAγ1 以弥补 OsTFIIAγ5 在水稻细菌性条斑病中的缺失。
Mol Plant Pathol. 2018 Oct;19(10):2248-2262. doi: 10.1111/mpp.12696. Epub 2018 Aug 7.

本文引用的文献

1
The OsICS1 is directly regulated by OsWRKY6 and increases resistance against Xanthomonas oryzae pv. oryzae.OsICS1 受 OsWRKY6 直接调控，增强了对稻白叶枯病菌的抗性。
Planta. 2024 Apr 17;259(6):124. doi: 10.1007/s00425-024-04405-2.
2
Jasmonate activates secondary cell wall biosynthesis through MYC2-MYB46 module.茉莉酸通过MYC2-MYB46模块激活次生细胞壁生物合成。
Plant J. 2024 Feb;117(4):1099-1114. doi: 10.1111/tpj.16541. Epub 2023 Nov 20.
3
Tal6b/AvrXa27A, a hidden TALE targeting the susceptibility gene OsSWEET11a and the resistance gene Xa27 in rice.
Tal6b/AvrXa27A，一个针对水稻感病基因 OsSWEET11a 和抗病基因 Xa27 的隐藏 TALE。
Plant Commun. 2024 Feb 12;5(2):100721. doi: 10.1016/j.xplc.2023.100721. Epub 2023 Sep 20.
4
A varied AvrXa23-like TALE enables the bacterial blight pathogen to avoid being trapped by Xa23 resistance gene in rice.一种多样化的 AvrXa23 样 TALE 使水稻细菌性条斑病菌能够避免被 Xa23 抗性基因所困。
J Adv Res. 2022 Dec;42:263-272. doi: 10.1016/j.jare.2022.01.007. Epub 2022 Jan 29.
5
OsWRKY114 Inhibits ABA-Induced Susceptibility to pv. in Rice.OsWRKY114 抑制 ABA 诱导的水稻对 pv. 的易感性。
Int J Mol Sci. 2022 Aug 8;23(15):8825. doi: 10.3390/ijms23158825.
6
OsSWEET11b, a potential sixth leaf blight susceptibility gene involved in sugar transport-dependent male fertility.OsSWEET11b，一个参与糖转运依赖型雄性育性的第六个潜在的叶斑病易感性基因。
New Phytol. 2022 May;234(3):975-989. doi: 10.1111/nph.18054. Epub 2022 Mar 12.
7
The OsWRKY6 transcriptional cascade functions in basal defense and Xa1-mediated defense of rice against Xanthomonas oryzae pv. oryzae.OsWRKY6 转录级联反应在水稻基础防御和 Xa1 介导的对稻黄单胞菌 pv.oryzae 的防御中起作用。
Planta. 2022 Jan 25;255(2):47. doi: 10.1007/s00425-022-03830-5.
8
DNA features beyond the transcription factor binding site specify target recognition by plant MYC2-related bHLH proteins.除转录因子结合位点以外的 DNA 特征决定了植物 MYC2 相关 bHLH 蛋白的靶标识别。
Plant Commun. 2021 Aug 12;2(6):100232. doi: 10.1016/j.xplc.2021.100232. eCollection 2021 Nov 8.
9
Mitogen-activated protein kinase 6 negatively regulates secondary wall biosynthesis by modulating MYB46 protein stability in Arabidopsis thaliana.丝裂原活化蛋白激酶 6 通过调节拟南芥 MYB46 蛋白稳定性来负调控次生壁生物合成。
PLoS Genet. 2021 Apr 7;17(4):e1009510. doi: 10.1371/journal.pgen.1009510. eCollection 2021 Apr.
10
Thriving under Stress: How Plants Balance Growth and the Stress Response.在压力下茁壮成长：植物如何平衡生长与应激反应。
Dev Cell. 2020 Dec 7;55(5):529-543. doi: 10.1016/j.devcel.2020.10.012.