Shi Weiyan, Yang Zhiqiang, Fu Pengbin, Yang Yang
School of Medicine, Xiamen University, Xiamen, Fujian, China.
Department of Cardiology, School of Medicine, Xiang'an Hospital of Xiamen University, Xiamen University, Xiamen, Fujian, China.
Front Pharmacol. 2025 May 13;16:1569020. doi: 10.3389/fphar.2025.1569020. eCollection 2025.
Previous evidence has indicated that the role of 2-aminoadipic acid (2-AAA), a derivative of lysine catabolism, in mediating specific detrimental effects on glial cells, notably inhibiting astrocyte activation. In addition, intrathecal administration of 2-AAA has demonstrated significant efficacy in relieving mechanical hyperalgesia. With the growing application of metabolomics in biomedical research, substantial evidence now underscores 2-AAA's pivotal role in regulating glucose and lipid metabolism. As a novel biomarker, 2-AAA is linked to increased susceptibility to diabetes and has emerged as a critical regulator of glucose homeostasis. This review explores recent advancements in understanding 2-AAA's potential therapeutic applications, particularly in the context of metabolic diseases such as diabetes, obesity, and atherosclerosis. It also addresses existing research gaps and outlines future directions for developing 2-AAA-based therapies.
先前的证据表明，赖氨酸分解代谢的衍生物2-氨基己二酸（2-AAA）在介导对神经胶质细胞的特定有害作用方面发挥作用，特别是抑制星形胶质细胞的激活。此外，鞘内注射2-AAA已显示出在缓解机械性痛觉过敏方面具有显著疗效。随着代谢组学在生物医学研究中的应用不断增加，大量证据现在强调了2-AAA在调节葡萄糖和脂质代谢中的关键作用。作为一种新型生物标志物，2-AAA与糖尿病易感性增加有关，并已成为葡萄糖稳态的关键调节因子。这篇综述探讨了在理解2-AAA潜在治疗应用方面的最新进展，特别是在糖尿病、肥胖症和动脉粥样硬化等代谢性疾病的背景下。它还讨论了现有的研究空白，并概述了开发基于2-AAA的疗法的未来方向。
