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A Pharmacovigilance Study on Psychotropic Agent-Induced Urinary Retention Using the Japanese Adverse Drug Event Report Database.一项使用日本药品不良事件报告数据库开展的关于精神药物所致尿潴留的药物警戒研究。
Drugs Real World Outcomes. 2024 Dec;11(4):691-700. doi: 10.1007/s40801-024-00465-8. Epub 2024 Nov 13.
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Exploring clozapine use in severe psychiatric symptoms associated with autism spectrum disorder: A scoping review.探索氯氮平在自闭症谱系障碍相关严重精神症状中的应用:范围综述。
J Psychopharmacol. 2024 Apr;38(4):324-343. doi: 10.1177/02698811241241384. Epub 2024 Apr 4.
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National Survey on bladder and bowel dysfunctions in Autism Spectrum Disorder population.自闭症谱系障碍人群膀胱和肠道功能障碍全国调查。
Front Psychiatry. 2024 Mar 11;15:1140113. doi: 10.3389/fpsyt.2024.1140113. eCollection 2024.
4
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6
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Urological adverse drug reactions of psychotropic medication in psychiatric inpatients - A drug surveillance report from German-speaking countries.精神科住院患者精神药物的泌尿生殖系统不良反应 - 来自德语国家的药物监测报告。
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8
[Acute urine retention: Epidemiology, optimization of the care pathway and alternative to permanent bladder drainage].[急性尿潴留:流行病学、护理路径优化及永久性膀胱引流替代方案]
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10
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病例报告:因行为危机住院的患有严重自闭症的年轻成年人尿潴留病例系列

Case report: Case series of urinary retention in young adults with severe autism hospitalized for behavioral crisis.

作者信息

Nollace Leslie, Panagiotis Drolapas, Convertini Josephine, Grilo Nuno, Ansermot Nicolas, Guinchat Vincent

机构信息

Psychiatric Section of Mental Development, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.

出版信息

Front Psychiatry. 2025 May 13;16:1570436. doi: 10.3389/fpsyt.2025.1570436. eCollection 2025.

DOI:10.3389/fpsyt.2025.1570436
PMID:40433175
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12106420/
Abstract

BACKGROUND

Behavioral regressions in low verbal patients with severe autism constitute a dramatic challenge for clinicians. A physical comorbidity burden is often involved but difficult to evidence.

AIM

We present five cases of patients under 30 years old (three men and two women), recently hospitalized in a specialized multidisciplinary inpatient unit, settled in Lausanne University Hospital, and for which at some point, a urinary retention contributed to the constitution of a complex behavioral picture.

METHODS

For each patient, we report the individual risk factors, clinical presentation and the conditions for making the diagnosis.

RESULTS

As the usual guidelines for screening, management, and follow-up of urinary retentions are irrelevant in this population, we provide and discuss some recommendations: limitation of anticholinergic burden, strict application of the protocol for going to the toilet with training protocol, regularization of intestinal transit, daily bladder-scan control, and eventually use of Tamsulosin hydrochloride. These recommendations significantly improved the urinary status of our patients.

CONCLUSION

We conclude that chronic urinary retention is probably a recurrent and unrecognized feature in many young adults with autism and challenging behaviors, reflecting the long-term impact of iatrogenic medication and requiring a specific attention.

摘要

背景

重度自闭症的低语言能力患者出现行为退化,这对临床医生构成了巨大挑战。通常存在躯体共病负担,但难以证实。

目的

我们报告5例30岁以下患者(3名男性和2名女性)的情况,这些患者近期入住洛桑大学医院的一个专门的多学科住院单元,在病程中的某个阶段,尿潴留导致了复杂行为表现的形成。

方法

我们报告了每位患者的个体风险因素、临床表现及诊断条件。

结果

由于针对尿潴留的常规筛查、管理及随访指南对此类人群不适用,我们提供并讨论了一些建议:限制抗胆碱能药物负担、严格执行带训练方案的如厕规程、使肠道蠕动规律化、每日进行膀胱扫描监测,最终使用盐酸坦索罗辛。这些建议显著改善了我们患者的泌尿状况。

结论

我们得出结论,慢性尿潴留可能是许多患有自闭症和具有挑战性的行为的年轻成年人中反复出现且未被认识到的特征,反映了医源性用药的长期影响,需要给予特别关注。