Analysis of Gene Variant Frequencies in Iranian Population.

BACKGROUND

The cytochrome P450 (P450s or CYPs) enzyme family, particularly , significantly influences drug metabolism, handling approximately 20-25% of prescribed medications. Understanding genetic polymorphisms is crucial for personalized medicine and optimizing drug therapy in specific geographic and racial contexts. Given the complex nature of studying genotypes, this study aimed to assess the prevalence of rare star alleles, including rs267608319 (*31), rs1931013246 (*55), rs569439709 (*113), and rs747089665 (*135), within the Iranian population.

METHODS

Blood samples were obtained from 389 individuals across several ethnic groups in Tehran, Iran, from May to December 2022. PCR was used to amplify the region containing the desired variant. Genotyping was performed using the Sanger sequencing method.

RESULTS

Our analysis revealed a high frequency of normal alleles for all four studied variants, indicating the absence of the risk allele in the Iranian population. These findings suggest that the studied alleles have no apparent effect on various ethnic groups in Iran.

CONCLUSION

The Iranian population has a typical genetic makeup for variations, impacting medication prescribing. Understanding genetic differences is crucial for personalized drug therapies. Further research into Iranian genetic variations is essential for advancing personalized medicine.