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流感病毒基因组突变、宿主屏障与跨物种传播

Influenza Virus Genomic Mutations, Host Barrier and Cross-species Transmission.

作者信息

Xiong Wenyan, Zhang Zongde

机构信息

Inflammation & Allergic Diseases Research Unit, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China.

The School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, 646000, China.

出版信息

Curr Genomics. 2025;26(3):161-174. doi: 10.2174/0113892029316603240926051325. Epub 2024 Oct 11.

DOI:10.2174/0113892029316603240926051325
PMID:40433418
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12105246/
Abstract

Influenza is a global epidemic infectious disease that causes a significant number of illnesses and deaths annually. Influenza exhibits high variability and infectivity, constantly jumping from birds to mammals. Genomic mutations of the influenza virus are a central mechanism leading to viral variation and antigenic evolution. Amino acid substitutions and avoidance of microRNA recognition elements are crucial in facilitating the virus to cross species barriers. This review summarizes the types of genomic mutations in the influenza virus, their roles and mechanisms in crossing species barriers, and analyzes the impact of these mutations on human health.

摘要

流感是一种全球性的流行性传染病，每年导致大量疾病和死亡。流感具有高度变异性和传染性，不断从鸟类传播到哺乳动物。流感病毒的基因组突变是导致病毒变异和抗原进化的核心机制。氨基酸替换和逃避微小RNA识别元件在促进病毒跨越物种屏障方面至关重要。本综述总结了流感病毒基因组突变的类型、它们在跨越物种屏障中的作用和机制，并分析了这些突变对人类健康的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/564a/12105246/ea9ffc57b1cc/CG-26-3-161_F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/564a/12105246/2d790dee8157/CG-26-3-161_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/564a/12105246/7165fcab47b8/CG-26-3-161_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/564a/12105246/ff0b6b2d00a1/CG-26-3-161_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/564a/12105246/0a340505278c/CG-26-3-161_F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/564a/12105246/ea9ffc57b1cc/CG-26-3-161_F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/564a/12105246/2d790dee8157/CG-26-3-161_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/564a/12105246/7165fcab47b8/CG-26-3-161_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/564a/12105246/ff0b6b2d00a1/CG-26-3-161_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/564a/12105246/0a340505278c/CG-26-3-161_F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/564a/12105246/ea9ffc57b1cc/CG-26-3-161_F5.jpg

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本文引用的文献

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Genetic Characterization and Phylogeographic Analysis of the First H13N6 Avian Influenza Virus Isolated from Vega Gull in South Korea.从韩国 Vega 鸥中分离出的首例 H13N6 禽流感病毒的遗传特征和系统地理学分析。
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MicroRNA-based therapeutics for inflammatory disorders of the microbiota-gut-brain axis.基于 microRNA 的微生态失调-肠-脑轴炎症性疾病治疗方法。
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PLoS Pathog. 2023 Jul 27;19(7):e1011476. doi: 10.1371/journal.ppat.1011476. eCollection 2023 Jul.
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