[Characteristics of the effect of psychotropic preparations on the synaptosomal uptake of monoamines].

The authors investigated the ability of psychotropic drugs of different classes (psychostimulants, antidepressants and tranquilizers) to inhibit the reverse synaptosomal uptake of monoamine neurotransmitters in the rat brain. The psychostimulants amphetamine and cocaine (50 microM) powerfully suppressed noradrenaline, dopamine and serotonin transport without influencing GABA uptake. Phenazepam (50 microM) negligibly decreased the reverse synaptosomal uptake chiefly of noradrenaline. Studies of the antidepressants evidenced that inkazan is a highly selective inhibitor of the reverse uptake of serotonin, whereas other antidepressants such as zimelidine, imipramine and norzimelidine were discovered to inhibit the uptake of serotonin to a larger extent than that of other transmitters. The antidepressants pyrazidol and viloxazine turned out to be non-selective inhibitors of the transport of all monoamines tested. Iproniazide and moclobamide appeared inactive as regards the reverse uptake of monoamine neurotransmitters.