[抗精神病药和抗抑郁药对离体大鼠脑神经末梢γ-氨基丁酸-H3摄取过程的影响]
[Effect of neuroleptics and antidepressants on the process of gamma-aminobutyric acid-H3 uptake by isolated rat brain nerve endings].
作者信息
Raevskiĭ K S, Maĭsov N I
出版信息
Biull Eksp Biol Med. 1975 Jun;79(6):63-5.
The effects of phenothiazine neuropleptics--chlorpromazine, trifluoperazine, fluphenazine and of antidepressants-imipramine and phthoracizine on the GABA-H3 accumulation by synaptosomes of the rat cerebral cortex were studied. All neuroleptics were found to inhibit the process of neurotransmitter uptake by the brain synaptosomes. Antidepressants were less potent. Chlorpromazine had the highest inhibitory effect on GABA uptake and phthoracizine--the lowest. It is suggested that the influence of neurolptics on GABA uptake could play a certain role in the mode of a synaptic action of these drugs.
研究了吩噻嗪类抗精神病药（氯丙嗪、三氟拉嗪、氟奋乃静）及抗抑郁药（丙咪嗪、酞嗪）对大鼠大脑皮质突触体GABA-H3积聚的影响。发现所有抗精神病药均能抑制脑突触体摄取神经递质的过程。抗抑郁药的作用较弱。氯丙嗪对GABA摄取的抑制作用最强，而酞嗪的抑制作用最弱。提示抗精神病药对GABA摄取的影响可能在这些药物的突触作用方式中起一定作用。
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