血影蛋白二聚体对肌动蛋白聚合的影响。
Effect of spectrin dimer on actin polymerization.
作者信息
Strömqvist M, Backman L, Shanbhag V P
出版信息
FEBS Lett. 1985 Oct 7;190(1):15-20. doi: 10.1016/0014-5793(85)80417-8.
Spectrin dimer is shown to influence the polymerization behaviour of actin. The polymerization of both Mg2+- and Ca2+-actin is regulated by an enhancement in the rate of nucleation and a fragmentation of preformed actin filaments. In addition, spectrin decreases the critical concentration of Ca2+-actin but not that of Mg2+-actin. This suggests that the two types of actin may differ in their interaction with spectrin dimer probably due to the different conformations. Band 4.1 elevates the effects of spectrin under non-equilibrium conditions but its contribution is less at steady state.
血影蛋白二聚体被证明会影响肌动蛋白的聚合行为。Mg2+ -肌动蛋白和Ca2+ -肌动蛋白的聚合都通过成核速率的提高和预先形成的肌动蛋白丝的断裂来调节。此外，血影蛋白降低了Ca2+ -肌动蛋白的临界浓度，但不降低Mg2+ -肌动蛋白的临界浓度。这表明这两种类型的肌动蛋白与血影蛋白二聚体的相互作用可能不同，这可能是由于构象不同。在非平衡条件下，带4.1增强了血影蛋白的作用，但在稳态时其贡献较小。
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