Tack J, Palsson O S, Bangdiwala S I, Schol J, Carbone F, Van Den Houte K, Broeders B, Drossman D, Dumitrascu D L, Fang X, Fukudo S, Ghoshal U C, Kellow J, Khatun R, Okeke E, Quigley E M, Schmulson M, Simrén M, Whitehead W E, Whorwell P, Sperber A D
Rome Foundation Research Institute, Raleigh, North Carolina, USA.
Translational Research Center for Gastrointestinal Disorders (TARGID), University of Leuven, Belgium.
Aliment Pharmacol Ther. 2025 Aug;62(3):330-339. doi: 10.1111/apt.70189. Epub 2025 May 28.
Functional dyspepsia (FD) is one of the most common disorders of gut-brain interaction (DGBI). Varying reported population prevalences probably reflect different definitions and methodological approaches.
To study the prevalence and impact of FD and its subgroups in an internet survey.
A total of 54,127 respondents from 26 countries completed the survey including the Rome IV diagnostic questionnaire, Patient Health Questionnaire-4 (PHQ-4), PHQ-12, PROMIS Global-10, demographics, and medical history. Respondents reporting a history of relevant organic disease, or fulfilling criteria for self-induced or cyclic vomiting, or cannabinoid hyperemesis were excluded.
Rome IV FD prevalence was 7.2% (range 2.2%-12.3%), significantly higher in women and decreased with age. The most prominent subtype was postprandial distress syndrome (PDS) (66.6%). Rome IV IBS was found in 26.1% of those fulfilling FD criteria. Functional heartburn and chronic nausea and vomiting criteria were fulfilled in, respectively, 9.0% and 7.0%. Fulfilling FD symptom criteria was significantly associated with increased prevalence of anxiety and depression and with lower quality of life and higher healthcare seeking behaviour.
Rome IV FD is one of the most prevalent DGBI globally. Across countries, it is associated with female sex, younger age, psychological distress, reduced quality of life, and higher health care utilisation. PDS is the dominant subgroup. Overlapping other DGBI are present in a minority.
功能性消化不良（FD）是最常见的肠-脑互动障碍（DGBI）之一。不同报告的人群患病率可能反映了不同的定义和方法。
在一项互联网调查中研究FD及其亚组的患病率和影响。
来自26个国家的54127名受访者完成了调查，包括罗马IV诊断问卷、患者健康问卷-4（PHQ-4）、PHQ-12、PROMIS全球-10、人口统计学和病史。报告有相关器质性疾病史、或符合自我诱导或周期性呕吐标准、或大麻素性呕吐综合征标准的受访者被排除。
罗马IV型FD患病率为7.2%（范围2.2%-12.3%），女性患病率显著更高，且随年龄增长而降低。最突出的亚型是餐后不适综合征（PDS）（66.6%）。在符合FD标准的人群中，发现罗马IV型肠易激综合征（IBS）的比例为26.1%。功能性烧心和慢性恶心呕吐标准的符合率分别为9.0%和7.0%。符合FD症状标准与焦虑和抑郁患病率增加、生活质量降低以及更高的就医行为显著相关。
罗马IV型FD是全球最普遍的DGBI之一。在各个国家，它与女性、年轻、心理困扰、生活质量降低以及更高的医疗保健利用率相关。PDS是主要亚组。少数人存在与其他DGBI重叠的情况。
