Ribatti Domenico
Department of Translational Biomedicine and Neuroscience, University of Bari, Bari, Italy.
Clin Exp Med. 2025 May 28;25(1):181. doi: 10.1007/s10238-025-01720-0.
The cardiovascular system is the first functional organ system to develop in the vertebrate embryo. The primitive heart and primitive vascular plexus are formed through vasculogenesis and thereafter through angiogenesis. After the establishment of new connections within the vascular network, a pruning and remodeling process occurs after which some branches are stabilized, whereas others regress. The aim of this article is to describe the most common pruning and remodeling forms, which take place during organogenesis in the experimental and human systems.
心血管系统是脊椎动物胚胎中第一个发育的功能器官系统。原始心脏和原始血管丛通过血管生成形成，此后通过血管生成形成。在血管网络内建立新的连接后，会发生修剪和重塑过程，之后一些分支会稳定下来，而另一些则会退化。本文的目的是描述在实验系统和人体系统的器官发生过程中发生的最常见的修剪和重塑形式。
