Gause W C, Marsh J A
Dev Comp Immunol. 1985 Summer;9(3):465-75. doi: 10.1016/0145-305x(85)90009-6.
The effects of dietary thyroxine (T4) supplementation for specific periods on the early development of the primary lymphoid organs and spontaneous autoimmune thyroiditis (SAT) was examined in the Obese (OS) strain of chicken. Effects of the treatments on concentrations of serum growth hormone (GH) and testosterone were also determined. All treatment groups were examined at 6 weeks. T4 supplementation did not affect serum testosterone or GH concentrations. However T4 given for the first three weeks resulted in significantly increased bursa weights, no change in thymic weights, significantly decreased lymphoid infiltration of the thyroid and reduced thyroglobulin autoantibody levels (TgAAb). T4 supplementation for the full six weeks resulted in no change in bursal weight, significantly increased thymic weight, significantly decreased lymphoid infiltration of the thyroid, and reduced TgAAb. These results suggest that the effects of T4 supplementation on SAT and immune development are dependent on the interval during which it is administered and that testosterone and GH probably do not mediate these effects.
在肥胖（OS）品系鸡中，研究了特定时期补充膳食甲状腺素（T4）对初级淋巴器官早期发育和自发性自身免疫性甲状腺炎（SAT）的影响。还测定了这些处理对血清生长激素（GH）和睾酮浓度的影响。所有处理组均在6周时进行检查。补充T4不影响血清睾酮或GH浓度。然而，在前三周给予T4导致法氏囊重量显著增加，胸腺重量无变化，甲状腺的淋巴细胞浸润显著减少，甲状腺球蛋白自身抗体水平（TgAAb）降低。在整个六周内补充T4导致法氏囊重量无变化，胸腺重量显著增加，甲状腺的淋巴细胞浸润显著减少，TgAAb降低。这些结果表明，补充T4对SAT和免疫发育的影响取决于给药间隔，睾酮和GH可能不介导这些影响。
