Samkian Adrian E, Poonswat Kasam, Virgil Scott C, Stoltz Brian M
Warren and Katharine Schlinger Laboratory of Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, MC 101-20, Pasadena, California 91125, United States.
Org Lett. 2025 Jun 6;27(22):5876-5879. doi: 10.1021/acs.orglett.5c01750. Epub 2025 May 28.
We report a modular three-component annulation among propargyl zinc reagents, unsaturated 1,3-dicarbonyls, and electrophiles to enable rapid construction of highly substituted cyclopentenes. In addition to optimization studies, a range of substrates were investigated. These products can be readily diversified to highlight their synthetic utility.
我们报道了炔丙基锌试剂、不饱和1,3-二羰基化合物和亲电试剂之间的模块化三组分环化反应，可实现高度取代环戊烯的快速构建。除了优化研究外，还对一系列底物进行了研究。这些产物可很容易地多样化，以突出它们的合成效用。
