秋水仙碱对实验性卟啉症的抑制作用。

Inhibition of experimental porphyria with colchicine.

作者信息

Wysenbeek A J, Schoenfeld N, Epstein O, Greenblat Y, Atsmon A

出版信息

Int J Biochem. 1985;17(8):937-40. doi: 10.1016/0020-711x(85)90179-x.

Abstract

Colchicine at the concentrations of 5 X 10(-7) - 5 X 10(-6) M decreased significantly both delta-aminolevulinic acid synthase activity and accumulation of porphyrins in monolayers of chick embryo liver cells induced by allyl-isopropylacetamide, by 3,5-diethoxycarbonyl-1,4-dihydrocollidine or by phenobarbitone. No effect was noted in non-induced cells. In rats, colchicine 0.3 mg/kg, reduced significantly the allyl-isopropylacetamide induced increase in the activity of delta-aminolevulinic acid synthase in the liver and the concentration of urinary porphyrins while it did not affect these parameters in non-induced rats.

摘要

浓度为5×10⁻⁷ - 5×10⁻⁶ M的秋水仙碱可显著降低烯丙基异丙基乙酰胺、3,5 - 二乙氧基羰基 - 1,4 - 二氢可力丁或苯巴比妥诱导的鸡胚肝细胞单层中δ-氨基乙酰丙酸合酶活性和卟啉积累。在未诱导的细胞中未观察到影响。在大鼠中，0.3 mg/kg的秋水仙碱可显著降低烯丙基异丙基乙酰胺诱导的肝脏中δ-氨基乙酰丙酸合酶活性增加以及尿卟啉浓度，而对未诱导的大鼠这些参数无影响。