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Emergent BAX-mutated clonal hematopoiesis after venetoclax-based therapy for breast cancer.

作者信息

Tiong Ing S, Nguyen Tamia, Chua Chong C, Teh Charis E, Muttiah Christine, Ftouni Sarah, Seymour John F, Gray Daniel, Roberts Andrew W, Dawson Sarah-Jane, Lindeman Geoffrey J, Blombery Piers

机构信息

Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.

Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia.

出版信息

Blood Adv. 2025 Sep 9;9(17):4391-4395. doi: 10.1182/bloodadvances.2025016063.

DOI:10.1182/bloodadvances.2025016063
PMID:40435508
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12405625/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/643c/12405625/49e51d5865ef/BLOODA_ADV-2025-016063-gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/643c/12405625/2c9fa572b7b9/BLOODA_ADV-2025-016063-gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/643c/12405625/49e51d5865ef/BLOODA_ADV-2025-016063-gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/643c/12405625/2c9fa572b7b9/BLOODA_ADV-2025-016063-gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/643c/12405625/49e51d5865ef/BLOODA_ADV-2025-016063-gr2.jpg

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本文引用的文献

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Analysis of somatic mutations in whole blood from 200,618 individuals identifies pervasive positive selection and novel drivers of clonal hematopoiesis.对200,618名个体全血中的体细胞突变进行分析，确定了广泛的正向选择和克隆性造血的新驱动因素。
Nat Genet. 2024 Jun;56(6):1147-1155. doi: 10.1038/s41588-024-01755-1. Epub 2024 May 14.
2
Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia.BAX 获得性突变赋予急性髓系白血病对 BH3 模拟物治疗的耐药性。
Blood. 2023 Feb 9;141(6):634-644. doi: 10.1182/blood.2022016090.
3
Discovering the drivers of clonal hematopoiesis.
发现克隆性造血的驱动因素。
Nat Commun. 2022 Jul 23;13(1):4267. doi: 10.1038/s41467-022-31878-0.
4
Clonal hematopoiesis, myeloid disorders and BAX-mutated myelopoiesis in patients receiving venetoclax for CLL.接受 venetoclax 治疗 CLL 的患者中的克隆性造血、髓系疾病和 BAX 突变性髓系增生
Blood. 2022 Feb 24;139(8):1198-1207. doi: 10.1182/blood.2021012775.
5
Multiple BCL2 mutations cooccurring with Gly101Val emerge in chronic lymphocytic leukemia progression on venetoclax.在 Venetoclax 治疗慢性淋巴细胞白血病的进展中，出现了 BCL2 多个突变与 Gly101Val 共存的情况。
Blood. 2020 Mar 5;135(10):773-777. doi: 10.1182/blood.2019004205.
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A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2-Positive Metastatic Breast Cancer.一项 Venetoclax（BCL2 抑制剂）联合他莫昔芬治疗激素受体阳性和 BCL2 阳性转移性乳腺癌的 Ib 期剂量递增和扩展研究。
Cancer Discov. 2019 Mar;9(3):354-369. doi: 10.1158/2159-8290.CD-18-1151. Epub 2018 Dec 5.
7
PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy.PPM1D 突变驱动细胞毒性化疗后的克隆性造血。
Cell Stem Cell. 2018 Nov 1;23(5):700-713.e6. doi: 10.1016/j.stem.2018.10.004.
8
Hematopoietic lineage distribution and evolutionary dynamics of clonal hematopoiesis.克隆性造血的造血谱系分布和进化动态。
Leukemia. 2018 Sep;32(9):1908-1919. doi: 10.1038/s41375-018-0047-7. Epub 2018 Mar 1.
9
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Cell Stem Cell. 2017 Sep 7;21(3):374-382.e4. doi: 10.1016/j.stem.2017.07.010. Epub 2017 Aug 10.
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Oncogene. 2016 Apr 14;35(15):1877-87. doi: 10.1038/onc.2015.287. Epub 2015 Aug 10.