Wittmann T, Crenner F, Pousse A, Grenier J F
Digestion. 1985;32(2):114-23. doi: 10.1159/000199227.
The aim of this work was to compare the effects of massive jejunal and ileal resections on intestinal motility using an electromyographic technique. Male Wistar rats were used: in the first group a massive jejunal resection was performed, conserving a 7-cm segment after the ligament of Treitz; the rats of the second group underwent an ileal resection, preserving 7 cm of the terminal ileum. Motility was studied at the 10th and 30th postoperative days by means of electrodes implanted throughout the remaining bowel and was expressed by the pattern of recurrence of the migrating myoelectric complex (MMC). In a fasting state, in both transected and resected animals at the 10th postoperative day, the gradient in the duration of MMC along the intestine still existed. However, on the 30th postoperative day, in animals with jejunal resection only, there was an adaptive process: the duration of MMC in the remaining jejunum was significantly increased to the duration in the ileum. After the end of the postprandial inhibition of the appearance of the MMC, on the 10th postoperative day there was a significant decrease in the duration of MMC in the ileum in both types of resection, compared to the controls. However, on the 30th postoperative day, the duration of MMC returned to its control value. In conclusion, jejunal resection seems to induce more important adaptive processes in intestinal motility than does ileal resection. The different results are discussed.
本研究旨在采用肌电图技术比较大面积空肠和回肠切除对肠道运动的影响。选用雄性Wistar大鼠：第一组进行大面积空肠切除，在Treitz韧带后保留7厘米肠段；第二组大鼠进行回肠切除，保留末端回肠7厘米。在术后第10天和第30天，通过植入剩余肠道的电极研究肠道运动，并以移行性肌电复合波（MMC）的复发模式表示。在禁食状态下，术后第10天，横断和切除的动物沿肠道的MMC持续时间梯度仍然存在。然而，在术后第30天，仅进行空肠切除的动物出现了适应性过程：剩余空肠中MMC的持续时间显著增加至回肠中的持续时间。在餐后MMC出现抑制结束后，术后第10天，与对照组相比，两种切除类型的回肠中MMC的持续时间均显著缩短。然而，在术后第30天，MMC的持续时间恢复到对照值。总之，空肠切除似乎比回肠切除在肠道运动中诱导更重要的适应性过程。对不同结果进行了讨论。
