Zhang Yani, Qi Rui, Luo Xinwei, Lu Jin, Zhao Xueying, Wang Liyuan
School of Basic Medical Sciences, Bengbu Medical University, Bengbu, China.
Department of Clinical Medicine, Bengbu Medical University, Bengbu, China.
Sci Rep. 2025 May 28;15(1):18760. doi: 10.1038/s41598-025-04024-1.
This study investigated the relationship between serum Alpha-Klotho (α-Klotho) levels and bone mineral density (BMD) in patients with chronic kidney disease (CKD) using data from the National Health and Nutrition Examination Survey (NHANES) 2011-2016. A population of 781 CKD patients aged ≥ 40 years was analyzed using multiple linear regression models to examine the association between serum α-Klotho levels and BMD at different skeletal sites, with adjustments for demographic, lifestyle, and clinical factors. Results showed that serum α-Klotho levels were significantly correlated with BMD at thoracic spine (β = 0.004 g/cm, p = 0.00264), total BMD (β = 0.003 g/cm, p = 0.02591), and trunk BMD (β = 0.002 g/cm, p = 0.03708), while no significant associations were observed at the left leg, lumbar spine, or pelvis. Stratified analyses showed that the association was more pronounced in men, non-Hispanic whites, those with a body mass index greater than 29.9 kg/m, and those without hypertension and diabetes. The inconsistent associations observed across different skeletal sites suggest that it remains unclear whether serum α-Klotho levels are consistently associated with BMD in CKD patients. Additionally, the cross-sectional design precludes any determination of causality in the observed site-specific associations.
本研究利用2011 - 2016年美国国家健康与营养检查调查（NHANES）的数据，调查了慢性肾脏病（CKD）患者血清α-klotho（α-Klotho）水平与骨密度（BMD）之间的关系。使用多元线性回归模型分析了781例年龄≥40岁的CKD患者，以检验血清α-Klotho水平与不同骨骼部位骨密度之间的关联，并对人口统计学、生活方式和临床因素进行了调整。结果显示，血清α-Klotho水平与胸椎骨密度（β = 0.004 g/cm，p = 0.00264）、总骨密度（β = 0.003 g/cm，p = 0.02591）和躯干骨密度（β = 0.002 g/cm，p =
