Hilfenhaus J, Weinmann E, Majer M, Barth R, Jaeger O
J Infect Dis. 1977 May;135(5):846-9.
The treatment of rabies-infected cynomolgus monkeys (Macaca fascicularis) with human interferon after exposure was studied. The monkeys were infected with rabies street virus by the intramuscular route; larger than or equal to 24 hr after infection, human interferon was administered intramuscularly or by lumbar spinal injection into the cerebrospinal fluid. Whereas 90% of the infected untreated monkeys died, 40%-80% of animals treated with interferon survived. No or only low levels of neutralizing antibody to rabies virus were found in the sera of monkeys that survived after a single intramuscular injection of human interferon. Distinctly higher antibody titers, however, were detected in the sera of surviving monkeys that had been given six consecutive intralumbar doses of interferon beginning three days after infections. Therefore, we conclude that in these monkeys rabies virus propagated until it spread into the central nervous system, where further viral replication was inhibited by the human interferon administered by the intralumbar route.
研究了暴露后用人干扰素治疗感染狂犬病的食蟹猴（猕猴）。通过肌肉注射途径使猴子感染狂犬病街毒；感染后大于或等于24小时，通过肌肉注射或经腰椎穿刺注入脑脊液的方式给予人干扰素。90%未经治疗的感染猴子死亡，而接受干扰素治疗的动物存活率为40%-80%。单次肌肉注射人干扰素后存活的猴子血清中未发现或仅发现低水平的狂犬病病毒中和抗体。然而，在感染后三天开始连续六次经腰椎给予干扰素的存活猴子血清中检测到明显更高的抗体滴度。因此，我们得出结论，在这些猴子中，狂犬病病毒一直繁殖到扩散到中枢神经系统，在中枢神经系统中，经腰椎途径给予的人干扰素抑制了病毒的进一步复制。
