Iftikhar Irum, Barkat Kashif, Badshah Syed Faisal, Ashraf Muhammad Umer, Mehmood Yasir, Anjum Irfan, Shazly Gamal A, Metouekel Amira, Younous Youssouf Ali, Bourhia Mohammed
Faculty of Pharmacy, The University of Lahore, Lahore, 54000, Punjab, Pakistan.
Faculty of Health Sciences, Equator University of Science and Technology, Masaka, Uganda.
Sci Rep. 2025 May 28;15(1):18686. doi: 10.1038/s41598-025-96739-4.
Recent study aimed to fabricate pH responsive, intelligent, Pluronic F127 based polymeric system for controlled delivery of Famciclovir. Nine formulations were developed through free radical polymerization. Polymeric system exhibited pH dependent swelling by showing higher degree of swelling in simulated intestinal fluid of pH 7.4 while negligible swelling in simulated gastric fluid of pH 1.2. Drug loading increased with increase in percent water content. Famciclovir loading percent was found in range of 60.892% to 73.741%. In FTIR spectra, characteristic peaks were achieved confirming the successful grafting of drug in polymeric system. PXRD results demonstrated the conversion of crystalline nature of Famciclovir into an amorphous one in the loaded hydrogel. SEM confirmed the porous nature of hydrogel. Famciclovir loaded hydrogel showed superior thermal behavior as compared to the drug alone. In vitro Famciclovir release studies unveiled small quantity of drug release in simulated gastric fluid (25.55-34.89%) while maximal release in simulated intestinal fluid (90.12-99.13%) for 36 h was documented thereby confirming pH regulated release. Application of DD solver revealed that PLMA hydrogels followed zero order while First order was being followed by Famciclovir marketed tablet. No toxicity signs were observed in rabbits establishing the biosafety of system. Hence, the results suggest that Pluronic based polymeric system can act as promising carrier for controlled, site specific delivery of Famciclovir in intestine for prolonged period thereby reducing its dosing frequency and minimizing gastric side effects for treating Herpes and Varicella zoster infections.
最近的研究旨在制备一种基于泊洛沙姆F127的pH响应型智能聚合物系统，用于更昔洛韦的控释。通过自由基聚合制备了九种制剂。聚合物系统表现出pH依赖性溶胀，在pH 7.4的模拟肠液中溶胀程度较高，而在pH 1.2的模拟胃液中溶胀可忽略不计。载药量随含水量百分比的增加而增加。更昔洛韦载药量百分比在60.892%至73.741%范围内。在傅里叶变换红外光谱中，获得了特征峰，证实了药物在聚合物系统中的成功接枝。粉末X射线衍射结果表明，负载水凝胶中更昔洛韦的晶态转变为非晶态。扫描电子显微镜证实了水凝胶的多孔性质。与单独的药物相比，负载更昔洛韦的水凝胶表现出优异的热性能。体外更昔洛韦释放研究表明，在模拟胃液中药物释放量较少（25.55 - 34.89%），而在模拟肠液中36小时的最大释放量为（90.12 - 99.13%），从而证实了pH调节释放。应用DD求解器显示，聚（L-丙交酯-co-甲基丙烯酸）水凝胶遵循零级释放，而市售更昔洛韦片剂遵循一级释放。在兔子身上未观察到毒性迹象，证明了该系统的生物安全性。因此，结果表明基于泊洛沙姆的聚合物系统可作为一种有前景的载体，用于在肠道中长时间控制、定点递送更昔洛韦，从而降低其给药频率并将治疗疱疹和水痘带状疱疹感染的胃部副作用降至最低。
