Thang Nguyen Hoc, Chien Truong Bach, Cuong Dang Xuan
Faculty of Chemical Technology, Ho Chi Minh City University of Food Industry, 140 Le Trong Tan, Tan Phu Distrist, Ho Chi Minh City 700000, Vietnam.
Innovation and Entrepreneurship Center, Ho Chi Minh City University of Food Industry, 140 Le Trong Tan, Tan Phu Distrist, Ho Chi Minh City 700000, Vietnam.
Gels. 2023 Jun 27;9(7):523. doi: 10.3390/gels9070523.
Polymer-based hydrogels are hydrophilic polymer networks with crosslinks widely applied for drug delivery applications because of their ability to hold large amounts of water and biological fluids and control drug release based on their unique physicochemical properties and biocompatibility. Current trends in the development of hydrogel drug delivery systems involve the release of drugs in response to specific triggers such as pH, temperature, or enzymes for targeted drug delivery and to reduce the potential for systemic toxicity. In addition, developing injectable hydrogel formulations that are easily used and sustain drug release during this extended time is a growing interest. Another emerging trend in hydrogel drug delivery is the synthesis of nano hydrogels and other functional substances for improving targeted drug loading and release efficacy. Following these development trends, advanced hydrogels possessing mechanically improved properties, controlled release rates, and biocompatibility is developing as a focus of the field. More complex drug delivery systems such as multi-drug delivery and combination therapies will be developed based on these advancements. In addition, polymer-based hydrogels are gaining increasing attention in personalized medicine because of their ability to be tailored to a specific patient, for example, drug release rates, drug combinations, target-specific drug delivery, improvement of disease treatment effectiveness, and healthcare cost reduction. Overall, hydrogel application is advancing rapidly, towards more efficient and effective drug delivery systems in the future.
基于聚合物的水凝胶是具有交联结构的亲水性聚合物网络，由于其能够容纳大量的水和生物流体，并基于其独特的物理化学性质和生物相容性控制药物释放，因此被广泛应用于药物递送领域。水凝胶药物递送系统当前的发展趋势包括响应特定触发因素（如pH值、温度或酶）释放药物，以实现靶向药物递送并降低全身毒性的可能性。此外，开发易于使用且能在较长时间内持续释放药物的可注射水凝胶制剂也越来越受到关注。水凝胶药物递送的另一个新兴趋势是合成纳米水凝胶和其他功能物质，以提高靶向药物负载和释放效果。遵循这些发展趋势，具有机械性能改善、释放速率可控和生物相容性的先进水凝胶正在成为该领域的一个重点发展方向。基于这些进展，将开发更复杂的药物递送系统，如多药递送和联合疗法。此外，基于聚合物的水凝胶因其能够针对特定患者进行定制（例如药物释放速率、药物组合、靶向特定药物递送、提高疾病治疗效果和降低医疗成本）而在个性化医疗中越来越受到关注。总体而言，水凝胶的应用正在迅速发展，朝着未来更高效、更有效的药物递送系统迈进。
