急性胰腺炎患者的视网膜微血管改变：一项光学相干断层扫描血管造影（OCTA）观察性研究
Retinal microvasculature alteration in patients with acute pancreatitis: an observational OCTA study.
作者信息
Qian Xian-Zhe, Hu Jin-Yu, Zeng Yan-Mei, Wei Hong, Wang Xiao-Yu, Chen Cheng, Ge Qian-Min, Zou Jie, Zhou Xian-Mei, Ling Qian, He Liang-Qi, Liao Xuan, Shao Yi
机构信息
Department of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China.
Ophthalmology Department of Affiliated Hospital, Medical School of Ophthalmology and Optometry, North Sichuan Medical College, Nanchong, 637000, Sichuan Province, China.
出版信息
Eur J Med Res. 2025 May 28;30(1):426. doi: 10.1186/s40001-025-02566-8.
OBJECTIVE
To evaluate changes in retinal layer thickness and microvascular density in pancreatitis patients using optical coherence tomography angiography (OCTA).
METHODS
The study involved 16 pancreatitis patients and 16 healthy controls. Each participant underwent a superficial OCTA scan, with images divided into nine subregions to compare macular retinal thickness (RT) and superficial vascular density (SVD) between groups.
RESULTS
Pancreatitis patients exhibited reduced retinal thickness in specific macular areas, including inner, full, and outer layers (p < 0.05). Additionally, decreased superficial vascular density was noted in inner superior (IS), outer superior (OS), inner nasal (IN), and outer nasal (ON) regions (p < 0.05). ROC curve analysis showed high diagnostic accuracy for full-layer inner superior, outer superior, and outer inferior thickness with areas under the curve of 0.9429, 0.9233, and 0.9990, respectively.
CONCLUSIONS
Pancreatitis is associated with macular retinal thinning and decreased superficial vascular density, offering potential for improved diagnostic imaging.
目的
利用光学相干断层扫描血管造影（OCTA）评估胰腺炎患者视网膜层厚度和微血管密度的变化。
方法
该研究纳入了16例胰腺炎患者和16名健康对照者。每位参与者均接受了一次浅表OCTA扫描，图像被分为九个亚区域，以比较两组之间的黄斑视网膜厚度（RT）和浅表血管密度（SVD）。
结果
胰腺炎患者在特定的黄斑区域，包括内层、全层和外层，视网膜厚度降低（p < 0.05）。此外，在内上（IS）、外上（OS）、内鼻（IN）和外鼻（ON）区域观察到浅表血管密度降低（p < 0.05）。ROC曲线分析显示，全层内上、外上和外下厚度具有较高的诊断准确性，曲线下面积分别为0.9429、0.9233和0.9990。
结论
胰腺炎与黄斑视网膜变薄和浅表血管密度降低有关，为改进诊断成像提供了潜力。
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