Zhang Lei, Liu Mengdi, Zhao Jinjin, Li Shaodan
College of Chemistry and Materials Science, Hebei Normal University, Shijiazhuang 050024, China.
Testing and Analysis Center, Hebei Normal University, Shijiazhuang 050024, China.
J Org Chem. 2025 Jun 6;90(22):7468-7475. doi: 10.1021/acs.joc.5c00911. Epub 2025 May 28.
A vanadium-catalyzed radical cascade trifluoromethylation/(bi)cyclization of alkenes and 1,7-enynes with Togni-II reagent for the synthesis of trifluoromethylated oxindoles, isoquinoline-1,3-diones, and indeno[1,2-]quinolines has been developed. These transformations show broad substrate compatibility and high regioselectivity. Mechanistic studies reveal that a CF radical is generated to trigger the ensuing 5- and 6- cyclization, as well as the cascade 6-/5- bicyclization processes.
已开发出一种钒催化的烯烃和1,7-烯炔与Togni-II试剂的自由基串联三氟甲基化/（双）环化反应，用于合成三氟甲基化的氧化吲哚、异喹啉-1,3-二酮和茚并[1,2-c]喹啉。这些转化反应显示出广泛的底物兼容性和高区域选择性。机理研究表明，会生成一个CF自由基来引发随后的5-和6-环化反应，以及串联的6-/5-双环化过程。
