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AgRP1调节雌性青鳉繁殖季节依赖性的摄食行为。

AgRP1 modulates breeding season-dependent feeding behavior in female medaka.

作者信息

Tagui Yurika, Takeda Shingo, Waida Hiroyo, Kitahara Shoichi, Kimura Tomoki, Kanda Shinji, Oka Yoshitaka, Hayashi Yu, Umatani Chie

机构信息

Graduate School of Science, The University of Tokyo, Tokyo, Japan.

Department of Applied Physics, The University of Tokyo, Tokyo, Japan.

出版信息

Elife. 2025 May 29;13:RP100996. doi: 10.7554/eLife.100996.

DOI:10.7554/eLife.100996
PMID:40439220
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12122003/
Abstract

Feeding and reproduction are known to be closely correlated with each other, and the seasonal breeders show breeding season-dependent feeding behavior. However, most model animals do not have definite breeding seasonality, and the mechanisms for such feeding behavior remain unclear. Here, we focused on female medaka (); they show breeding season-dependent feeding behavior, and their condition of breeding season can be experimentally controlled by day-length. We first demonstrated that, among previously reported feeding-related peptides (neuropeptides involved in feeding), agouti-related peptide 1 () and neuropeptide y b () show higher brain expression under the breeding condition than under the non-breeding one. Combined with analysis of knockout medaka, we obtained results to suggest that long day-induced sexually mature condition, especially ovarian estrogenic signals, increase the expressions of in the brain, which results in increased food intake to promote reproduction. Our findings advance the understanding of neural mechanisms of feeding behavior for reproductive success.

摘要

已知摄食与繁殖密切相关，季节性繁殖动物表现出与繁殖季节相关的摄食行为。然而，大多数模式动物没有明确的繁殖季节性，这种摄食行为的机制仍不清楚。在这里，我们聚焦于雌性青鳉；它们表现出与繁殖季节相关的摄食行为，并且它们繁殖季节的状况可以通过光周期进行实验控制。我们首先证明，在先前报道的与摄食相关的肽（参与摄食的神经肽）中，刺鼠相关肽1（AgRP1）和神经肽Yb（Npyb）在繁殖条件下的大脑表达高于非繁殖条件。结合对AgRP1基因敲除青鳉的分析，我们得到的结果表明，长日照诱导的性成熟状态，尤其是卵巢雌激素信号，会增加大脑中AgRP1和Npyb的表达，从而导致食物摄入量增加以促进繁殖。我们的研究结果推进了对为实现繁殖成功而进行的摄食行为神经机制的理解。

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本文引用的文献

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Role of estrogen receptors in health and disease.雌激素受体在健康和疾病中的作用。
Front Endocrinol (Lausanne). 2022 Aug 18;13:839005. doi: 10.3389/fendo.2022.839005. eCollection 2022.
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Estrogen upregulates the firing activity of hypothalamic gonadotropin-releasing hormone (GnRH1) neurons in the evening in female medaka.雌激素在傍晚时上调雌性青鳉下丘脑促性腺激素释放激素（GnRH1）神经元的放电活动。
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Co-existing Neuropeptide FF and Gonadotropin-Releasing Hormone 3 Coordinately Modulate Male Sexual Behavior.
共存的神经肽 FF 和促性腺激素释放激素 3 协同调节雄性性行为。
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Neural and Hormonal Control of Sexual Behavior.性性行为的神经和激素控制。
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17β-estradiol promotes acute refeeding in hungry mice via membrane-initiated ERα signaling.17β-雌二醇通过膜起始 ERα 信号促进饥饿小鼠的急性再喂养。
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Neuropeptide Y deficiency induces anxiety-like behaviours in zebrafish (Danio rerio).神经肽 Y 缺乏会诱导斑马鱼（Danio rerio）出现类似焦虑的行为。
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Examination of methods for manipulating serum 17β-Estradiol (E2) levels by analysis of blood E2 concentration in medaka (Oryzias latipes).通过分析麦瑞加拉鲮（Oryzias latipes）血液中的 17β-雌二醇（E2）浓度，研究操纵血清 E2 水平的方法。
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