Yii Valerie, Moussa Anthony, Triwongwaranat Daranporn, Smith Blake R C, Bhoyrul Bevin
Sinclair Dermatology Investigational Research Education and Clinical Trials (DIRECT), East Melbourne, Vic., Australia.
Sinclair Dermatology, East Melbourne, Vic., Australia.
Dermatol Surg. 2025 Jul 14. doi: 10.1097/DSS.0000000000004707.
Primary cicatricial alopecia (PCA) refers to a clinically diverse group of inflammatory hair loss disorders characterized by the irreversible destruction and scarring of hair follicles. Hair transplantation (follicular unit extraction [FUE] or strip harvesting follicular unit transplantation [FUT]) has been proposed as a treatment for inactive PCA.
This study aims to evaluate the efficacy and safety of HT for the management of PCA.
A systematic review was conducted to identify studies assessing treatment of PCA in adults (≥18 years) with FUE or FUT. The primary outcome measure was follicular unit (FU) graft survival rate. Secondary outcomes included postoperative complications and patient satisfaction.
Eight observational studies with a total of 123 patients met the inclusion criteria. Overall, the weighted FU graft survival rate after HT was 82.7% at 7 to 12 months, 73.3% at 13 to 24 months, 58.4% at 25 to 36 months, 55.4% at 37 to 48 months and 39.6% at 49 to 72 months. Four patients developed reactivation of their disease after HT.
The FU graft survival rate after FUE or FUT for the management of inactive PCA peaks at 1 year and diminishes over time.
原发性瘢痕性脱发（PCA）是一组临床症状多样的炎症性脱发疾病，其特征为毛囊的不可逆破坏和瘢痕形成。毛发移植（毛囊单位提取术[FUE]或条带切取毛囊单位移植术[FUT]）已被提议作为静止期PCA的一种治疗方法。
本研究旨在评估毛发移植治疗PCA的疗效和安全性。
进行一项系统评价，以识别评估采用FUE或FUT治疗成人（≥18岁）PCA的研究。主要结局指标为毛囊单位（FU）移植成活率。次要结局包括术后并发症和患者满意度。
8项观察性研究共123例患者符合纳入标准。总体而言，毛发移植术后7至12个月加权FU移植成活率为82.7%，13至24个月为73.3%，25至36个月为58.4%，37至48个月为55.4%，49至72个月为39.6%。4例患者在毛发移植后疾病复发。
采用FUE或FUT治疗静止期PCA后的FU移植成活率在1年时达到峰值，并随时间下降。
