Wang Aiping, Pan Qin, Zhang Jing, Gong Shaoxin, Zhang Fumei, Liang Na, Yang Yunhua, Jiang Zhisheng
Department of Physiology, Institute of Neuroscience Research, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China; Department of Physiology, Institute of Neuroscience Research, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
Biomed Pharmacother. 2025 Jul;188:118206. doi: 10.1016/j.biopha.2025.118206. Epub 2025 May 28.
To provide an overview of the interaction between endothelial inflammatory response and pulmonary hypertension (PH), and how the associated inflammatory response can be regulated to improve the life quality of patients with PH. A systematic review was performed to focus on the recent research about the subject.
Accumulated evidence suggests that the inflammatory response of endothelial cells (ECs) plays an important role in the occurrence and progression of various types of PH. The inflammatory response of ECs leads to ECs hyper-proliferation, anti-apoptosis, endothelial barrier function damage and vasoconstriction through activating multiple pathways and secreting the mediators, and finally accelerating pulmonary vascular remodeling and the progression of PH.
The inflammatory response mediated by ECs plays a significant role in the development of PH. A better exploration of the role of endothelial inflammatory response in PH will be conducive to effectively prevent and treat PH.
概述内皮细胞炎症反应与肺动脉高压（PH）之间的相互作用，以及如何调节相关炎症反应以提高PH患者的生活质量。进行了一项系统综述，重点关注该主题的最新研究。
越来越多的证据表明，内皮细胞（ECs）的炎症反应在各种类型PH的发生和发展中起重要作用。ECs的炎症反应通过激活多种途径和分泌介质，导致ECs过度增殖、抗凋亡、内皮屏障功能受损和血管收缩，最终加速肺血管重塑和PH的进展。
ECs介导的炎症反应在PH的发展中起重要作用。更好地探索内皮炎症反应在PH中的作用将有助于有效预防和治疗PH。
